Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
J Dermatolog Treat. 2013 Oct;24(5):327-31. doi: 10.3109/09546634.2012.660519. Epub 2012 Mar 4.
Bullous pemphigoid (BP) is the most common blistering autoimmune skin disease. Combination methotrexate (MTX) and prednisone therapy is an effective short-term treatment for BP.
To determine the average length and frequency with which MTX and prednisone combination therapy leads to long-term remission off therapy.
A retrospective chart review of 16 of our patients with BP was conducted. Patients were treated with the combination regimen of MTX and prednisone, followed by us for at least 1 year, and had long-term follow-up data.
The average length of time from initiating MTX and prednisone therapy to complete disease control was 3.8 months. Eight of 16 patients were in remission off BP therapy with combination MTX and prednisone therapy. The average length of treatment in this subgroup was 25.3 months and patients were followed for a mean of 5.5 years since initiating therapy. Three additional patients were in remission (with a mean treatment time short of the 25.3 month average) undergoing tapering of BP therapy.
Two year MTX and prednisone combination therapy is a safe, inexpensive, and effective treatment for BP that can result in long-term remission off therapy.
大疱性类天疱疮（BP）是最常见的水疱性自身免疫性皮肤病。甲氨蝶呤（MTX）和泼尼松联合治疗是 BP 的有效短期治疗方法。
确定 MTX 和泼尼松联合治疗导致长期停药缓解的平均持续时间和频率。
对 16 例 BP 患者进行回顾性图表审查。患者接受 MTX 和泼尼松联合治疗方案治疗，随后由我们进行至少 1 年的随访，并具有长期随访数据。
从开始 MTX 和泼尼松治疗到完全控制疾病的平均时间为 3.8 个月。16 例患者中有 8 例在接受 MTX 和泼尼松联合治疗后缓解。该亚组的平均治疗时间为 25.3 个月，患者从开始治疗起平均随访 5.5 年。另外 3 名患者在接受 BP 治疗的减量治疗时缓解（平均治疗时间短于 25.3 个月）。
两年 MTX 和泼尼松联合治疗是 BP 的一种安全、廉价且有效的治疗方法，可导致长期停药缓解。
