Lees W E, Kalinka S, Meech J, Capper S J, Cook N D, Kay J
Department of Biochemistry, University of Wales College of Cardiff, UK.
FEBS Lett. 1990 Oct 29;273(1-2):99-102. doi: 10.1016/0014-5793(90)81060-2.
Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further.
高纯度的组织蛋白酶D将人 big内皮素1-38加工成类内皮素片段，但在所采用的条件下似乎未生成内皮素1-21。相比之下，人组织蛋白酶E在相同条件下可将人big内皮素特异性切割成内皮素1-21和C末端片段，但不会进一步降解任何一种产物。
