MUC1、MUC2、MUC5AC 和 MUC5B 在乳腺黏液性病变中的表达。

Expression of MUC1, MUC2, MUC5AC and MUC5B in mucinous lesions of the breast.

机构信息

Department of Pathology, Ajou University Medical Center, Suwon, Korea.

出版信息

Pathobiology. 2012;79(3):144-53. doi: 10.1159/000334086. Epub 2012 Jan 20.

DOI:10.1159/000334086

PMID:22269464

Abstract

OBJECTIVE

The purpose of this study was to investigate the expression of MUC1, MUC2, MUC5AC and MUC5B in breast mucinous lesions.

METHODS

Immunohistochemical staining of MUC1, MUC2, MUC5AC, MUC5B and synaptophysin was performed in 78 cases of mucinous carcinoma (MC), 36 cases of mucocele-like lesions (MLL) and 13 cases of solid papillary carcinoma (SPC). MC was classified as type A or type B and MLL was classified as MLL, MLL with atypical ductal hyperplasia and MLL with ductal carcinoma in situ.

RESULTS

MUC1 was expressed in MC type A and MLL with luminal/apical pattern, while MC type B and SPC showed membrano-cytoplasmic expression of MUC1 (p < 0.001). A luminal/apical or luminal/apical + cytoplasmic pattern of MUC2 expression was observed in MC type A, while MC type B and SPC showed membrano-cytoplasmic MUC2 expression (p < 0.001). On MUC5B staining, MC type A and MLL were negative, while MC type B and SPC showed membrano-cytoplasmic expression (p = 0.011). The positive rate for synaptophysin was higher in MC type B and SPC than in MLL and MC type A (p = 0.001).

CONCLUSIONS

Similar MUC phenotypes were observed between MLL and MC type A and between MC type B and SPC.

摘要

目的

本研究旨在探讨黏蛋白 1（MUC1）、黏蛋白 2（MUC2）、黏蛋白 5AC（MUC5AC）和黏蛋白 5B（MUC5B）在乳腺黏液性病变中的表达。

方法

对 78 例黏液癌（MC）、36 例黏液囊肿样病变（MLL）和 13 例实性乳头状癌（SPC）进行 MUC1、MUC2、MUC5AC、MUC5B 和突触素免疫组织化学染色。MC 分为 A 型或 B 型，MLL 分为 MLL、伴非典型导管增生的 MLL 和伴导管原位癌的 MLL。

结果

MUC1 在 MC 型 A 和腔面/顶端模式的 MLL 中表达，而 MC 型 B 和 SPC 则表现为 MUC1 的膜细胞质表达（p＜0.001）。MUC2 的腔面/顶端或腔面/顶端+细胞质表达模式在 MC 型 A 中观察到，而 MC 型 B 和 SPC 则表现为 MUC2 的膜细胞质表达（p＜0.001）。在 MUC5B 染色中，MC 型 A 和 MLL 为阴性，而 MC 型 B 和 SPC 则表现为膜细胞质表达（p=0.011）。MC 型 B 和 SPC 的突触素阳性率高于 MLL 和 MC 型 A（p=0.001）。