Matsukita S, Nomoto M, Kitajima S, Tanaka S, Goto M, Irimura T, Kim Y S, Sato E, Yonezawa S
Department of Pathology, Kagoshima University Faculty of Medicine and Department of Pathology, Kagoshima Medical Association Hospital, Kagoshima, Japan.
Histopathology. 2003 Jan;42(1):26-36. doi: 10.1046/j.1365-2559.2003.01530.x.
Mucinous carcinoma of the breast usually shows less frequent lymph node metastasis and more favourable outcome compared with invasive ductal carcinoma. The aim of this study is to compare the expression profiles of several mucins in mucinous carcinomas and invasive ductal carcinomas to gain insight into the relationship between the less aggressive biological nature of mucinous carcinoma and the role of mucins.
We examined the expression profiles of MUC1 (membrane-bound mucin) of different glycoforms (from non-glycosylated form to fully glycosylated form), MUC2 (intestinal type secretory mucin), MUC5AC (gastric surface type secretory mucin) and MUC6 (gastric pyloric gland type secretory mucin) in 17 mucinous carcinomas and 46 invasive ductal carcinomas using immunohistochemistry. Various glycoforms of MUC1 were expressed frequently in both mucinous carcinomas (65-100%) and invasive ductal carcinomas (92-100%), although non-glycosylated MUC1 (MUC1/CORE) and fully glycosylated MUC1 (MUC1/HMFG-1) showed significantly lower expression rates in mucinous carcinomas compared with those in invasive ductal carcinomas. The expression rates of MUC2 (94%) and MUC6 (71%) in mucinous carcinomas were significantly higher than those of MUC2 (15%) and MUC6 (15%) in invasive ductal carcinomas. There was no significant difference in the expression rate of MUC5AC in mucinous carcinomas (12%) and that in invasive ductal carcinomas (4%).
The expression rate of MUC1/CORE and MUC1/HMFG-1, which is related to poor prognosis in the gastric and colorectal cancers, is low in mucinous carcinomas. The high expression rate of gel-forming secretory mucins (MUC2 and MUC6) in mucinous carcinoma suggests that high production of these types of mucins may act as a barrier to cancerous extension resulting in their less aggressive biological behaviour.
与浸润性导管癌相比，乳腺黏液癌通常显示出较低的淋巴结转移频率和更良好的预后。本研究的目的是比较黏液癌和浸润性导管癌中几种黏蛋白的表达谱，以深入了解黏液癌侵袭性较低的生物学特性与黏蛋白作用之间的关系。
我们采用免疫组织化学方法检测了17例黏液癌和46例浸润性导管癌中不同糖型（从非糖基化形式到完全糖基化形式）的MUC1（膜结合黏蛋白）、MUC2（肠型分泌性黏蛋白）、MUC5AC（胃表面型分泌性黏蛋白）和MUC6（胃幽门腺型分泌性黏蛋白）的表达谱。MUC1的各种糖型在黏液癌（65 - 100%）和浸润性导管癌（92 - 100%）中均频繁表达，尽管非糖基化的MUC1（MUC1/CORE）和完全糖基化的MUC1（MUC1/HMFG - 1）在黏液癌中的表达率显著低于浸润性导管癌。黏液癌中MUC2（94%）和MUC6（71%）的表达率显著高于浸润性导管癌中MUC2（15%）和MUC6（15%）的表达率。黏液癌中MUC5AC的表达率（12%）与浸润性导管癌中MUC5AC的表达率（4%）无显著差异。
与胃癌和结直肠癌预后不良相关的MUC1/CORE和MUC1/HMFG - 1在黏液癌中的表达率较低。黏液癌中凝胶形成性分泌黏蛋白（MUC2和MUC6）的高表达率表明，这些类型黏蛋白的高产量可能作为癌性扩展的屏障，导致其侵袭性较低的生物学行为。
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