Lyons C J, Vickers S F, Lee J P
Moorfields Eye Hospital, London.
Eye (Lond). 1990;4 ( Pt 4):538-42. doi: 10.1038/eye.1990.74.
We report our experience with the use of Botulinum toxin injection in 38 patients (64 injections) with severe dysthyroid strabismus. Three quarters of the injections led to a decrease in the angle of the squint by a mean 75% of the initial deviation. The average duration of effect was two months. Twenty six patients went on to surgery after stabilisation of their squint and endocrine status. Six patients achieved a stable long-term result with Botulinum toxin only. We suggest these results of treatment of early dysthyroid myopathy are more consistent with the characteristics of inflammatory spasm than contracture. The value of Botulinum toxin as a temporary means of maintaining binocularity in these young patients is discussed.
我们报告了对38例（共64次注射）重度甲状腺功能障碍性斜视患者使用肉毒杆菌毒素注射的经验。四分之三的注射使斜视角度减小，平均减小幅度为初始偏差的75%。平均效果持续时间为两个月。26例患者在斜视和内分泌状况稳定后接受了手术。6例患者仅通过肉毒杆菌毒素就取得了稳定的长期效果。我们认为，早期甲状腺功能障碍性肌病的这些治疗结果与炎症性痉挛而非挛缩的特征更为一致。文中讨论了肉毒杆菌毒素作为维持这些年轻患者双眼视功能的一种临时手段的价值。
