Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa 216-8511, Japan.
Mod Rheumatol. 2012 Sep;22(5):783-6. doi: 10.1007/s10165-011-0576-7. Epub 2012 Jan 21.
We present the case of a 43-year-old man diagnosed with HLA-B39-positive spondyloarthritis who developed cutaneous lesions consistent with cutaneous polyarteritis nodosa (CPN). Previous studies indicated an elevated incidence of HLA-B39 in HLA-B27-negative Japanese patients with spondyloarthritis. This case suggested that CPN may also occur in association with forms of HLA-B39-positive spondyloarthritis. The rarity of this association is emphasized. Therapy with corticosteroid and methotrexate improved both the cutaneous lesions and the clinical symptoms of spondyloarthritis.
我们报告了 1 例 HLA-B39 阳性的脊柱关节炎患者，该患者发生了符合结节性多动脉炎皮肤病变（CPN）的皮肤损害。先前的研究表明，HLA-B39 在 HLA-B27 阴性的日本脊柱关节炎患者中的发病率较高。该病例提示 CPN 也可能与 HLA-B39 阳性的脊柱关节炎有关。强调了这种关联的罕见性。皮质类固醇和甲氨蝶呤治疗改善了皮肤损害和脊柱关节炎的临床症状。
