孕激素宫内节育器治疗 2 级子宫内膜癌青少年患者。
Progestin intrauterine device in an adolescent with grade 2 endometrial cancer.
机构信息
From the Department of Gynecology and Obstetrics, the Johns Hopkins Medical Institutions, Baltimore, Maryland; and the Departments of Gynecologic Oncology and Pathology, the University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Obstet Gynecol. 2012 Feb;119(2 Pt 2):423-426. doi: 10.1097/AOG.0b013e318234d97c.
Abstract
BACKGROUND
The treatment of endometrial cancer in young women who desire future fertility poses several challenges. Oral progestin and progestin-releasing intrauterine devices (IUDs) have been shown to result in regression of endometrial hyperplasia and grade 1 endometrioid endometrial carcinoma. However, limited data are available on the use of these methods in women with grade 2 disease.
CASE
An 18-year-old nulliparous woman was diagnosed with a grade 2 endometrial adenocarcinoma. She desired future fertility and therefore underwent placement of a levonorgestrel-releasing IUD. The patient subsequently underwent endometrial sampling every 3 months and remained disease-free 13 months after initial IUD placement.
CONCLUSION
A progestin-releasing IUD may be a valid treatment option for grade 2 endometrial cancer in young women who desire to retain fertility.
摘要
背景
对于希望保留生育能力的年轻女性，子宫内膜癌的治疗存在一些挑战。已证实口服孕激素和孕激素释放宫内节育器（IUD）可使子宫内膜增生和 1 级子宫内膜样腺癌消退。然而，关于这些方法在 2 级疾病患者中的应用，数据有限。
病例
一名 18 岁的未婚妇女被诊断为 2 级子宫内膜腺癌。她希望保留生育能力，因此放置了左炔诺孕酮释放 IUD。患者随后每 3 个月进行子宫内膜取样，在最初放置 IUD 后 13 个月仍未出现疾病。
结论
对于希望保留生育能力的年轻女性，孕激素释放 IUD 可能是治疗 2 级子宫内膜癌的有效选择。
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