Schlitter A M, Esposito I
Institut für Pathologie, Technische Universität München, Ismaninger Strasse 22, Munich, Germany.
Chirurg. 2012 Feb;83(2):110-5. doi: 10.1007/s00104-011-2181-x.
Intraductal papillary mucinous neoplasms (IPMN) are precursor lesions of ductal adenocarcinoma of the pancreas and one of the most common cystic entities in this organ. Branch and main duct types are further distinguished based on the tumor localization. An additional classification is based on the predominant architecture and immunohistochemical profile with four prognostic relevant subtypes, gastric, intestinal, pancreato-biliary and oncocytic. This review provides an overview about the malignant potential of the different subtypes and the prognosis of associated invasive tumors and gives recommendations for the pathological assessment of resection specimens with IPMNs.
导管内乳头状黏液性肿瘤(IPMN)是胰腺导管腺癌的前驱病变,也是该器官最常见的囊性病变之一。根据肿瘤定位可进一步区分分支型和主胰管型。另一种分类是基于主要结构和免疫组化特征,分为四种与预后相关的亚型,即胃型、肠型、胰胆管型和嗜酸细胞型。本综述概述了不同亚型的恶性潜能以及相关浸润性肿瘤的预后,并对IPMN切除标本的病理评估提出建议。