Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey.
J Thromb Thrombolysis. 2012 Apr;33(3):239-45. doi: 10.1007/s11239-011-0668-4.
Some evidence suggests that chronic inflammation plays a critical role in the development and progression of coronary artery ectasia. Lectin-like oxidized low-density lipoprotein receptor-1 is involved in multiple phases of vascular dysfunction, including endothelial dysfunction, atherogenesis, initiation of plaque rupture, and restenosis. The objectives was to study the purpose of the current study was to determine whether soluble lectin-like oxidized low-density lipoprotein receptor-1 is associated with isolated coronary artery ectasia patients. Forty-six patients with isolated coronary artery ectasia without stenosis and 46 control subjects with angiographically normal coronary arteries were included in this study. Lectin-like oxidized low-density lipoprotein receptor-1 levels were measured in serum by sandwich enzyme-linked immunosorbent assay. Baseline characteristics of the two groups were similar. Plasma levels of lectin-like oxidized low-density lipoprotein receptor-1 were significantly higher in the coronary artery ectasia group than normal coronary artery group (1.7 ± 0.8 ng/ml vs. 1.1 ± 0.3 ng/ml, P < 0.001, respectively). No correlation was found between plasma soluble lectin-like oxidized low-density lipoprotein receptor-1 levels and different types of ectasia in patients with coronary artery ectasia. In this study, we found significantly higher levels of soluble lectin-like oxidized low-density lipoprotein receptor-1 in coronary artery ectasia patients when compared to control subjects with normal coronary arteries, suggesting that soluble lectin-like oxidized low-density lipoprotein receptor-1 may be involved in the pathogenesis of coronary artery ectasia.
一些证据表明，慢性炎症在冠状动脉扩张的发生和发展中起着关键作用。凝集素样氧化型低密度脂蛋白受体-1 参与血管功能障碍的多个阶段，包括内皮功能障碍、动脉粥样硬化、斑块破裂的启动和再狭窄。本研究的目的是确定可溶性凝集素样氧化型低密度脂蛋白受体-1 是否与孤立性冠状动脉扩张患者有关。本研究纳入了 46 例无狭窄的孤立性冠状动脉扩张患者和 46 例冠状动脉造影正常的对照组。采用夹心酶联免疫吸附法测定血清中凝集素样氧化型低密度脂蛋白受体-1 水平。两组的基线特征相似。冠状动脉扩张组血浆凝集素样氧化型低密度脂蛋白受体-1 水平明显高于正常冠状动脉组（1.7±0.8ng/ml 比 1.1±0.3ng/ml，P<0.001）。冠状动脉扩张患者不同类型扩张与血浆可溶性凝集素样氧化型低密度脂蛋白受体-1 水平无相关性。在这项研究中，我们发现与正常冠状动脉的对照组相比，冠状动脉扩张患者的可溶性凝集素样氧化型低密度脂蛋白受体-1 水平显著升高，这表明可溶性凝集素样氧化型低密度脂蛋白受体-1 可能参与了冠状动脉扩张的发病机制。
