Department of Radiology, Takai Hospital, Tenri, Nara, Japan.
Ann Nucl Med. 2012 Apr;26(3):248-52. doi: 10.1007/s12149-011-0568-x. Epub 2012 Jan 21.
2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) is known to accumulate in benign conditions such as infection and inflammation as well as in malignancy. Vaccination may cause transient inflammation of lymph nodes, which may induce false-positive findings on FDG-positron emission tomography (PET) imaging. This study investigated the influence of influenza vaccination on FDG-PET/CT imaging in normal subjects.
Between November 2008 and March 2009, a total of 172 examinees underwent FDG-PET/CT during an annual cancer-screening program at our hospital, 83 of whom had a history of recent non-adjuvanted seasonal influenza vaccination. They were asked the date and injection site of the vaccination. Examinees were divided into 2 groups based on the interval after vaccination using a cutoff value of 7 days (1 week). Two double board-certified nuclear medicine physicians and radiologists visually interpreted the FDG-PET/CT images with reference to PET/CT fusion and CT images and checked the location and the number of abnormal accumulations by consensus reading.
Intervals between vaccination and FDG-PET were less than 7 days in 5 examinees, and 7 days or more in 78 examinees. Unexpected accumulations were visualized in 4 examinees in the axilla and medial upper arm, and all of them belonged to the group who underwent vaccination less than 7 days previously. In the second group there was no abnormal FDG accumulation.
Recent influenza vaccination before FDG-PET/CT examination may cause ipsilateral axillary lymph node accumulations, especially within several days after vaccination. Questionnaires about vaccination can help to avoid false interpretation of FDG avid axillary lymph nodes.
2-[(18)F]氟-2-脱氧-D: -葡萄糖（FDG）已知在感染和炎症等良性情况下以及恶性肿瘤中积聚。疫苗接种可能导致淋巴结短暂炎症，这可能导致 FDG 正电子发射断层扫描（PET）成像上的假阳性发现。本研究调查了流感疫苗接种对正常受试者 FDG-PET/CT 成像的影响。
2008 年 11 月至 2009 年 3 月，共有 172 名受检者在我们医院的年度癌症筛查计划中接受了 FDG-PET/CT 检查，其中 83 名受检者有近期非佐剂季节性流感疫苗接种史。他们被问到疫苗接种的日期和注射部位。受检者根据接种后间隔时间分为 2 组，使用 7 天（1 周）的截止值。两位双 board-certified 核医学医师和放射科医师参考 PET/CT 融合和 CT 图像进行 FDG-PET/CT 图像的视觉解释，并通过共识阅读检查异常积聚的位置和数量。
5 名受检者的接种与 FDG-PET 之间的间隔时间少于 7 天，78 名受检者的间隔时间为 7 天或更长。在腋下和上臂内侧，有 4 名受检者出现了意外的积聚，他们都属于接种后不到 7 天的那一组。第二组没有异常的 FDG 积聚。
在 FDG-PET/CT 检查前最近接种流感疫苗可能导致同侧腋窝淋巴结积聚，特别是在接种后几天内。关于疫苗接种的问卷可以帮助避免对 FDG 摄入的腋窝淋巴结的错误解释。
