Antoniou George A, Lazarides Miltos K, Patera Stefania, Antoniou Stavros A, Giannoukas Athanasios D, Georgiadis George S, Veletza Stavroula Vouliana
Department of Vascular Surgery, Democritus University of Thrace, Alexandroupolis, Greece.
Vascular. 2013 Feb;21(1):1-5. doi: 10.1258/vasc.2011.oa0322. Epub 2012 Jan 23.
The aim of the paper is to determine whether the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is associated with abdominal aortic aneurysm (AAA) and inguinal hernia. A case-control study was conducted in 264 subjects: 65 patients with AAA, 91 patients with inguinal hernia, 19 patients with both AAA and hernia, and 89 controls were investigated for the ACE I/D polymorphism. Genotype analysis was performed using a polymerase chain reaction technique. Significant differences in the genotype between the patient groups and controls were identified (aneurysm versus control, P = 0.011; aneurysm plus hernia versus control, P = 0.022; hernia versus control, P = 0.001), whereas no differences were found within patient groups. Patients with AAA and/or hernia had an increased prevalence of I/D heterozygosity, which persisted even after adjusting for differences in confounding clinical variables (aneurysm versus control, OR 0.3, 95% CI 0.2-0.8, P = 0.005; aneurysm plus hernia versus control, OR 0.3, 95% CI 0.1-0.9, P = 0.040; hernia versus control, OR 0.4, 95% CI 0.2-0.7, P = 0.004). In conclusion, an association between the heterozygote ACE I/D state and the presence of AAA and/or hernia was identified. The role of the ACE I/D polymorphism in aneurysm and hernia needs further investigation.
本文的目的是确定血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性是否与腹主动脉瘤（AAA）和腹股沟疝相关。对264名受试者进行了一项病例对照研究：65例AAA患者、91例腹股沟疝患者、19例同时患有AAA和疝的患者以及89名对照者接受了ACE I/D多态性检测。采用聚合酶链反应技术进行基因型分析。确定了患者组与对照组之间基因型存在显著差异（动脉瘤组与对照组，P = 0.011；动脉瘤合并疝组与对照组，P = 0.022；疝组与对照组，P = 0.001），而患者组内部未发现差异。患有AAA和/或疝的患者I/D杂合子患病率增加，即使在调整了混杂临床变量的差异后仍然存在（动脉瘤组与对照组，OR 0.3，95%CI 0.2 - 0.8，P = 0.005；动脉瘤合并疝组与对照组，OR 0.3，95%CI 0.1 - 0.9，P = 0.040；疝组与对照组，OR 0.4，95%CI 0.2 - 0.7，P = 0.004）。总之，确定了杂合子ACE I/D状态与AAA和/或疝的存在之间存在关联。ACE I/D多态性在动脉瘤和疝中的作用需要进一步研究。
