Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Dermatol Surg. 2012 Jun;38(6):893-7. doi: 10.1111/j.1524-4725.2012.02345.x. Epub 2012 Jan 24.
Published reports indicate that corticosteroid injections can prevent recurrence after keloid excision, but the side effects of repetitive intralesional steroid injections may preclude treatment maintenance. Additionally, few of these studies employed a standardized treatment protocol.
To analyze the results of a new uniform treatment protocol combining corticosteroid injections and ointment application designed to reduce recurrence rates after excisional surgery in individuals with keloids or hypertrophic scars.
As a standard procedure, the first corticosteroid injection took place after removal of the sutures and then once every 2 weeks after that until it had been done five times. In addition, all postsurgical wounds received self-administered steroid ointment application twice daily for 6 months after suture removal.
Postoperative follow-up in this series ranged from 24 to 57 months (median 32 months, mean 32.5 months). Recurrence occurred in three of the 21 keloid cases (14.3%) and one of the six hypertrophic scar cases (16.7%).
We evaluated a new standardized adjuvant corticosteroid therapy to prevent recurrence after surgical keloid or hypertrophic scar excision. Using this method, we achieved low recurrence rates.
已有研究报告表明,皮质类固醇注射可以预防瘢痕疙瘩切除术后的复发,但重复的皮质类固醇腔内注射的副作用可能会妨碍治疗的维持。此外,这些研究中很少采用标准化的治疗方案。
分析一种新的联合皮质类固醇注射和软膏应用的统一治疗方案的结果,该方案旨在降低切除手术后瘢痕疙瘩或增生性瘢痕患者的复发率。
作为标准程序,第一次皮质类固醇注射在缝线拆除后进行,然后每 2 周进行一次,直到进行了 5 次。此外,所有手术后的伤口在缝线拆除后 6 个月内每天接受两次自行涂抹类固醇软膏。
本系列的术后随访时间为 24 至 57 个月(中位数为 32 个月,平均为 32.5 个月)。21 例瘢痕疙瘩中有 3 例(14.3%)和 6 例增生性瘢痕中有 1 例(16.7%)复发。
我们评估了一种新的标准化辅助皮质类固醇治疗方法,以预防手术切除瘢痕疙瘩或增生性瘢痕后的复发。使用这种方法,我们实现了低复发率。