Institut Pasteur, Unité de Génétique des Biofilms, Paris, France.
FEMS Microbiol Rev. 2012 Sep;36(5):972-89. doi: 10.1111/j.1574-6976.2012.00328.x. Epub 2012 Mar 8.
Multi-species biofilm communities are environments in which complex but ill understood exchanges between bacteria occur. Although monospecies cultures are still widely used in the laboratory, new approaches have been undertaken to study interspecies interactions within mixed communities. This review describes our current understanding of competitive relationships involving nonbiocidal biosurfactants, enzymes, and metabolites produced by bacteria and other microorganisms. These molecules target all steps of biofilm formation, ranging from inhibition of initial adhesion to matrix degradation, jamming of cell-cell communications, and induction of biofilm dispersion. This review presents available data on nonbiocidal molecules and provides a new perspective on competitive interactions within biofilms that could lead to antibiofilm strategies of potential biomedical interest.
多物种生物膜群落是细菌之间发生复杂但尚未被充分理解的物质交换的环境。尽管单物种培养物在实验室中仍被广泛应用，但已采取新方法来研究混合群落中的种间相互作用。本综述描述了我们目前对涉及非杀菌性生物表面活性剂、酶和细菌及其他微生物产生的代谢物的竞争关系的理解。这些分子靶向生物膜形成的所有步骤，从抑制初始黏附到基质降解、阻断细胞间通讯以及诱导生物膜分散。本综述介绍了非杀菌性分子的现有数据，并提供了一个关于生物膜内竞争相互作用的新视角，这可能会导致具有潜在医学兴趣的抗生物膜策略。
