School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK,
Appl Microbiol Biotechnol. 2014 Dec;98(24):9915-29. doi: 10.1007/s00253-014-6169-6. Epub 2014 Oct 31.
Current microbial inhibition strategies based on planktonic bacterial physiology have been known to have limited efficacy on the growth of biofilm communities. This problem can be exacerbated by the emergence of increasingly resistant clinical strains. All aspects of biofilm measurement, monitoring, dispersal, control, and inhibition are becoming issues of increasing importance. Biosurfactants have merited renewed interest in both clinical and hygienic sectors due to their potential to disperse microbial biofilms in addition to many other advantages. The dispersal properties of biosurfactants have been shown to rival those of conventional inhibitory agents against bacterial and yeast biofilms. This makes them suitable candidates for use in new generations of microbial dispersal agents and for use as adjuvants for existing microbial suppression or eradication strategies. In this review, we explore aspects of biofilm characteristics and examine the contribution of biologically derived surface-active agents (biosurfactants) to the disruption or inhibition of microbial biofilms.
目前基于浮游细菌生理学的微生物抑制策略已被证明对生物膜群落的生长效果有限。这个问题可能会因临床菌株耐药性的增加而加剧。生物膜测量、监测、分散、控制和抑制的各个方面都变得越来越重要。由于生物表面活性剂除了具有许多其他优点外，还有可能分散微生物生物膜，因此它们在临床和卫生领域重新引起了人们的兴趣。生物表面活性剂的分散特性已被证明可与传统抑菌剂相媲美，能有效对抗细菌和酵母生物膜。这使它们成为新一代微生物分散剂的候选物，并可作为现有微生物抑制或消除策略的助剂。在这篇综述中，我们探讨了生物膜特性的各个方面，并研究了生物来源的表面活性剂（生物表面活性剂）对微生物生物膜的破坏或抑制作用。
