Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.
Dermatol Surg. 2012 May;38(5):736-40. doi: 10.1111/j.1524-4725.2012.02339.x. Epub 2012 Jan 24.
Generally, axillary hyperhidrosis (AH) is treated with antiperspirant agents, botulinum toxin, or local surgery. The effect of laser treatment on sweat secretion in patients with AH has not been investigated.
To evaluate the effect of diode laser epilation on the sweat rate of patients with AH.
We performed a randomized half-side controlled trial. Twenty-one patients were treated with 5 cycles of an 800-nm diode laser. Sweat rates were documented using gravimetry and a visual analogue scale. Histologic examination was performed in all patients before and after treatment.
A significant reduction in sweat rate was observed on the laser-treated (median 89 mg/min, range 42-208 mg/min vs 48 mg/min, range 17-119 mg/min; p < .001) and the untreated contralateral (median 78 mg/min, range 25-220 mg/min vs median 65 mg/min, range 24-399 mg/min; p = .04) sides, although no significant difference was found between the treated and untreated sides (p = .10).
Although we observed a significant decrease in sweat rate on laser-treated sites, laser epilation was not able to reduce the sweat rate significantly more than on the untreated contralateral side. These results probably indicate a placebo effect rather than a direct therapeutic effect of laser epilation.
一般来说，腋部多汗症（axillary hyperhidrosis，AH）采用止汗剂、肉毒毒素或局部手术治疗。激光治疗对 AH 患者汗液分泌的影响尚未得到研究。
评估二极管激光脱毛对 AH 患者出汗率的影响。
我们进行了一项随机半侧对照试验。21 例患者接受了 5 个周期的 800nm 二极管激光治疗。使用称重法和视觉模拟量表记录出汗率。所有患者在治疗前后均进行组织学检查。
激光治疗侧（中位数 89mg/min，范围 42-208mg/min 与 48mg/min，范围 17-119mg/min；p<0.001）和未治疗对侧（中位数 78mg/min，范围 25-220mg/min 与中位数 65mg/min，范围 24-399mg/min；p=0.04）的出汗率均显著降低，但治疗侧与未治疗侧之间无显著差异（p=0.10）。
尽管我们观察到激光治疗部位的出汗率显著降低，但激光脱毛并不能比未治疗的对侧显著降低出汗率。这些结果可能表明激光脱毛的作用是一种安慰剂效应，而不是直接的治疗作用。
