Paul Anna, Kranz Gottfried, Schindl Andreas, Kranz Georg S, Auff Eduard, Sycha Thomas
Department of Neurology, Medical University of Vienna, A-1090 Vienna, Austria.
Lasers Surg Med. 2010 Mar;42(3):211-4. doi: 10.1002/lsm.20891.
The possible interference of combined laser hair removal and Botulinum toxin A (BoNT/A) injections in the treatment of axillary hyperhidrosis has not previously been explored. In order to examine this potential interference, we assessed the effect of BoNT/A on axillary hyperhidrosis with and without concomitant diode laser axillary hair removal.
STUDY DESIGN/MATERIALS AND METHODS: In a prospective, double blind, randomized cross over trial, nine patients suffering from primary axillary hyperhidrosis were laser-treated on one randomly assigned axilla. One week later, both axillas were injected intradermally with BoNT/A (100 MU per axilla). During the same session, the previously untreated axilla was lasered. Axillary sweat rates (in g/5 minutes.) were determined by gravimetry and compared at rest, during mental exercise, and during physical exercise. Additionally, subjective outcome measures were assessed by a visual analogue scale, Dermatology Life Quality Index, and Global Clinical Impression score.
No differences were found regarding the effect of BoNT/A on previously laser-treated and laser co-treated sides over time course for any of the outcome parameters. Sweat production was reduced 3 weeks after BoNT/A treatment by 93.5% at rest, 96.5% during mental exercise, and 67% during physical exercise.
Concomitant laser hair removal does not interfere with BoNT/A treatment on axillary hyperhidrosis.
联合激光脱毛与A型肉毒杆菌毒素（BoNT/A）注射治疗腋窝多汗症时可能存在的干扰此前尚未被探究。为了研究这种潜在干扰，我们评估了BoNT/A在伴有或不伴有二极管激光腋窝脱毛的情况下对腋窝多汗症的治疗效果。
研究设计/材料与方法：在一项前瞻性、双盲、随机交叉试验中，9名原发性腋窝多汗症患者的一侧腋窝被随机分配接受激光治疗。一周后，双侧腋窝均皮内注射BoNT/A（每侧腋窝100 MU）。在同一疗程中，对之前未治疗的腋窝进行激光治疗。通过重量法测定腋窝出汗率（克/5分钟），并在静息、精神运动和体育锻炼期间进行比较。此外，通过视觉模拟量表、皮肤病生活质量指数和整体临床印象评分评估主观结果指标。
在任何结果参数的时间进程中，未发现BoNT/A对先前接受激光治疗和联合激光治疗的部位的效果存在差异。BoNT/A治疗3周后，静息时出汗量减少了93.5%，精神运动时减少了96.5%；体育锻炼时减少了67%。
联合激光脱毛不影响BoNT/A对腋窝多汗症的治疗效果。
