Division of Pulmonary Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Curr Opin Pulm Med. 2012 Mar;18(2):125-30. doi: 10.1097/MCP.0b013e32834f8194.
Several large epidemiologic studies have shown an association between chronic obstructive pulmonary disease (COPD) and osteoporosis. Recent studies have further implied an emphysema-specific association with low bone mineral density independent of obstruction severity.
This review will outline the studies demonstrating an independent association between radiographic emphysema and decreased bone mineral density and will discuss potential disease mechanisms, including systemic inflammation and immune-mediated factors, linking these disease processes.
Radiographic emphysema should be considered an independent risk factor in studies examining the mechanisms underlying COPD-related bone loss. Future research focused on the relationship between emphysema and low bone mineral density could provide mechanistic insight and result in the development of targeted therapies designed to halt progression of both disease processes.
几项大型的流行病学研究表明，慢性阻塞性肺疾病（COPD）与骨质疏松症之间存在关联。最近的研究进一步表明，肺气肿与骨密度降低之间存在独立于阻塞严重程度的特定关联。
本综述将概述表明放射影像学肺气肿与骨密度降低之间存在独立关联的研究，并讨论潜在的疾病机制，包括系统性炎症和免疫介导因素，将这些疾病过程联系起来。
放射影像学肺气肿应被视为研究 COPD 相关骨丢失机制时的一个独立危险因素。未来专注于肺气肿与低骨密度之间关系的研究可能会提供机制上的见解，并导致开发旨在阻止这两个疾病过程进展的靶向治疗方法。
