磺达肝癸钠相关性肝素诱导的血小板减少症。
Fondaparinux-associated heparin-induced thrombocytopenia.
作者信息
Burch Micah, Cooper Barry
机构信息
Department of Oncology, Baylor Charles A. Sammons Cancer Center and Baylor University Medical Center at Dallas.
出版信息
Proc (Bayl Univ Med Cent). 2012 Jan;25(1):13-5. doi: 10.1080/08998280.2012.11928771.
Abstract
Heparin-induced thrombocytopenia (HIT) is an immune-mediated clinical syndrome of thrombocytopenia and thrombosis occurring after exposure to heparin. HIT most commonly occurs after exposure to unfractionated heparin but has also been reported with low-molecular-weight heparin. To date, there have been very few reports of HIT with the pentasaccharide fondaparinux, and some have proposed fondaparinux as a treatment for HIT. This article presents two cases of HIT associated with fondaparinux use.
摘要
肝素诱导的血小板减少症（HIT）是一种免疫介导的临床综合征，表现为接触肝素后出现血小板减少和血栓形成。HIT最常发生在接触普通肝素后，但也有使用低分子肝素后发生的报道。迄今为止，关于戊糖磺达肝癸钠导致HIT的报道极少，一些人还提出将磺达肝癸钠作为HIT的一种治疗方法。本文介绍了两例与使用磺达肝癸钠相关的HIT病例。
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