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Clinical picture of heparin-induced thrombocytopenia (HIT) and its differentiation from non-HIT thrombocytopenia.肝素诱导的血小板减少症（HIT）的临床特征及其与非 HIT 性血小板减少症的鉴别。
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Fondaparinux-associated heparin-induced thrombocytopenia.磺达肝癸钠相关性肝素诱导的血小板减少症。
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Fondaparinux Failure in Heparin-Induced Thrombocytopenia With Acute Limb Ischemia: A Case Report and Literature Review.磺达肝癸钠治疗肝素诱导的血小板减少症伴急性肢体缺血失败：一例报告及文献综述
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1
Detection of Platelet-Activating Antibodies Associated with Heparin-Induced Thrombocytopenia.与肝素诱导的血小板减少症相关的血小板活化抗体的检测
J Clin Med. 2020 Apr 24;9(4):1226. doi: 10.3390/jcm9041226.
2
Heparin-induced Thrombocytopenia: Pathophysiology, Diagnosis and Management.肝素诱导的血小板减少症：病理生理学、诊断与管理
Cureus. 2020 Mar 24;12(3):e7385. doi: 10.7759/cureus.7385.
3
Diagnosis and management of heparin-induced thrombocytopenia.肝素诱导的血小板减少症的诊断与管理
Anaesth Crit Care Pain Med. 2020 Apr;39(2):291-310. doi: 10.1016/j.accpm.2020.03.012. Epub 2020 Apr 13.
4
The paradox of heparin induced thrombocytopenia-thrombosis, the role of fondaparinux and the need for new therapeutic strategies.肝素诱导的血小板减少症-血栓形成的矛盾、磺达肝癸钠的作用及新治疗策略的必要性
Int Angiol. 2020 Aug;39(4):350-351. doi: 10.23736/S0392-9590.20.04364-3. Epub 2020 Mar 26.
5
Perioperative Bleeding in Patients With Acute Coronary Syndrome Treated With Fondaparinux Versus Low-Molecular-Weight Heparin Before Coronary Artery Bypass Grafting.在冠状动脉旁路移植术前接受磺达肝素钠与低分子肝素治疗的急性冠状动脉综合征患者的围手术期出血。
Am J Cardiol. 2019 Feb 15;123(4):565-570. doi: 10.1016/j.amjcard.2018.11.028. Epub 2018 Nov 24.
6
HIT complicating fondaparinux prophylaxis: fondaparinux-dependent platelet activation as a marker for fondaparinux-induced HIT.磺达肝癸钠预防相关的肝素诱导的血小板减少症：依赖磺达肝癸钠的血小板活化作为磺达肝癸钠诱导的肝素诱导的血小板减少症的标志物。
Thromb Haemost. 2014 Dec;112(6):1319-22. doi: 10.1160/TH14-08-0711. Epub 2014 Oct 16.
7
Frequent off-label use of fondaparinux in patients with suspected acute heparin-induced thrombocytopenia (HIT)--findings from the GerHIT multi-centre registry study.疑似急性肝素诱导的血小板减少症（HIT）患者中频繁使用磺达肝癸钠的情况——来自德国肝素诱导血小板减少症（GerHIT）多中心注册研究的结果
Thromb Res. 2014 Jul;134(1):29-35. doi: 10.1016/j.thromres.2014.03.029. Epub 2014 Mar 18.
8
Heparin-induced thrombocytopenia: comparison between response to fondaparinux and lepirudin.肝素诱导的血小板减少症：磺达肝癸钠与来匹卢定的反应比较。
Int J Clin Pharm. 2011 Dec;33(6):997-1001. doi: 10.1007/s11096-011-9573-3. Epub 2011 Oct 16.
9
Thrombocytopenia during fondaparinux prophylaxis: HIT or something different?磺达肝癸钠预防期间的血小板减少症：是肝素诱导的血小板减少症还是其他情况？
Intern Emerg Med. 2010 Aug;5(4):361-3. doi: 10.1007/s11739-010-0379-4. Epub 2010 May 5.
10
Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux prophylaxis.低分子量肝素引起的迟发性肝素诱导的血小板减少症在磺达肝癸钠预防期间出现。
Am J Hematol. 2008 Nov;83(11):876-8. doi: 10.1002/ajh.21273.

磺达肝癸钠相关性血小板减少症

Fondaparinux-associated Thrombocytopenia.

作者信息

Malik Jahanzeb, Javed Nismat, Kamin Matiullah

机构信息

Dr. Jahanzeb Malik, Rawalpindi Institute of Cardiology, Rawalpindi, Pakistan.

Dr. Nismat Javed, Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan.

出版信息

Pak J Med Sci. 2021 Mar-Apr;37(2):598-599. doi: 10.12669/pjms.37.2.3522.

DOI:10.12669/pjms.37.2.3522
PMID:33679958
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7931326/
Abstract

Heparin-induced thrombocytopenia (HIT) is an immune-mediated condition causing thrombocytopenia and paradoxical thrombosis after exposure to heparin or low-molecular-weight heparin. It has been rarely reported by Fondaparinux, an artificial pentasaccharide similar to heparin. This manuscript presents a case of HIT associated with fondaparinux use.

摘要

肝素诱导的血小板减少症（HIT）是一种免疫介导的疾病，在接触肝素或低分子量肝素后可导致血小板减少和反常血栓形成。与肝素类似的人工合成五糖磺达肝癸钠引起HIT的情况鲜有报道。本文报告了1例与使用磺达肝癸钠相关的HIT病例。