Qi Meng, Zhao Guang-yu, Su Chang-jun, Yang Ting, Liu Yu
Department of Stomatology, Fourth Military Medical University, Xi'an, China.
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2011 Nov;27(11):1237-9.
To determine the age-related differences in the polysomnography (PSG) and clinical presentation of Chinese male adult subjects with obstructive sleep apnea (OSA), and attempt to identify the age-specific effects on the severity of sleep apnea.
This retrospective study included a cohort of 836 Chinese male a-dult subjects, who were diagnosed with OSA by the initial overnight PSG and recruited from the clinic population. The eligible subjects were classified into three different age groups: 312 young (mean 37. 07 years), 359 middle-aged(mean 52. 14 years) and 165 older (mean 69.43 years),and their polysomnographic findings and clinical presentation were assessed for the age-specific differences.
The AHI-TST between the middle-aged and older subjects was similar (P > 0. 05), but less severe than the young(P <0.01). This trend was also observed in obstructive AI,AHI-NREM, and AHI-REM. The minimum SaO2 was higher in middle-aged and older subjects than in the young ones(P < 0.01). Central Al became greater following age in-crease (P <0.05). In sleep architecture, the elderly had lower total sleep time, sleep duration NREM or REM, and sleep efficiency than the younger (P < 0. 01), whereas sleep latency and WASO became longer ( P < 0. 01).Across all study population, age significantly correlated with AHI (P<0.01), obstructive Al (P<0.01), central AI (P<0.01) and minimum SaO2 ( P < 0. 01). Multiple regression analyses identified that age as an independent variable associated with AHI, obstructive Al and central Al respective- ly, after adjusting for confounding factors.
In Chinese clinic subjects with OSA, age as an independent predictor associates with sleep apnea severity, presenting as decreased OSA and increased CSA with age.
确定中国成年男性阻塞性睡眠呼吸暂停（OSA）患者多导睡眠图（PSG）及临床表现的年龄相关差异，并尝试明确年龄对睡眠呼吸暂停严重程度的特定影响。
这项回顾性研究纳入了836名中国成年男性患者，这些患者通过首次夜间PSG诊断为OSA，且均来自门诊人群。符合条件的受试者被分为三个不同年龄组：312名年轻人（平均37.07岁）、359名中年人（平均52.14岁）和165名老年人（平均69.43岁），并评估他们多导睡眠图的结果和临床表现的年龄特异性差异。
中年和老年受试者之间的呼吸暂停低通气指数（AHI）与总睡眠时间（TST）比值相似（P>0.05），但比年轻受试者轻（P<0.01）。在阻塞性呼吸暂停低通气指数（AI）、非快速眼动期（NREM）AHI和快速眼动期（REM）AHI中也观察到了这种趋势。中年和老年受试者的最低血氧饱和度（SaO2）高于年轻受试者（P<0.01）。中枢性AI随着年龄增长而增加（P<0.05）。在睡眠结构方面，老年人的总睡眠时间、NREM或REM睡眠时间以及睡眠效率均低于年轻人（P<0.01），而睡眠潜伏期和觉醒时间（WASO）则更长（P<0.01）。在所有研究人群中，年龄与AHI（P<0.01）、阻塞性AI（P<0.01）、中枢性AI（P<0.01）和最低SaO2（P<0.01）显著相关。多元回归分析表明，在调整混杂因素后，年龄分别作为与AHI、阻塞性AI和中枢性AI相关的独立变量。
在中国门诊OSA患者中，年龄作为独立预测因素与睡眠呼吸暂停严重程度相关，表现为随着年龄增长OSA减少而中枢性睡眠呼吸暂停（CSA）增加。
