非糖尿病患者中蛋白尿与脂肪因子、炎症及胰岛素抵抗的关联

[Association of albuminuria with adipokines, inflammation and insulin resistance in non-diabetic subjects].

作者信息

Vasilescu R, Ionescu-Tîrgovişte C

机构信息

Spitalul Clinic Colentina, Bucureşti.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2011 Oct-Dec;115(4):1174-82.

PMID:22276466

Abstract

UNLABELLED

The objective of this study was to evaluate the association of traditional cardiovascular risk factors, adipokines, inflammation and insulin resistance with low-grade urinary albumin-to-creatinine ratio (ACR) in nondiabetic, healthy subjects.

MATERIAL AND METHODS

The study included 117 healthy subjects (64 men and 53 women), who were classified according to their body mass index (BMI) into three groups: lean (BMI<25 kg/m2), overweight (25< or =BMI<30 kg/m2) and obese (BMI> or =30 kg/m2).

RESULTS

ACR was higher in obese men and women compared to overweight and lean men and women (men - 3 mg/g vs. 6.1 mg/g vs. 8.9 mg/g, p=0.018; women - 2.1 mg/g vs. 6.7 mg/g vs. 9.1 mg/g, p=0.03). In univariate analyses ACR was associated in obese men with adiponectin (r=-0.43, p=0.021) and systolic blood pressure (r=0.51, p=0.006) and in non-obese men with systolic blood pressure (r=0.39, p=0.041). In women systolic blood pressure was the only determinant both in obese (r=0.49, p=0.022) and non-obese subjects (r=0.42, p=0.04).

CONCLUSIONS

Adiponectin is an important mediator of low-grade albuminuria in obese, non-diabetic men.

摘要

未标注

本研究的目的是评估非糖尿病健康受试者中传统心血管危险因素、脂肪因子、炎症和胰岛素抵抗与低级别尿白蛋白肌酐比值（ACR）之间的关联。

材料与方法

该研究纳入了117名健康受试者（64名男性和53名女性），根据他们的体重指数（BMI）分为三组：瘦（BMI<25 kg/m²）、超重（25≤BMI<30 kg/m²）和肥胖（BMI≥30 kg/m²）。

结果

与超重和瘦的男性及女性相比，肥胖男性和女性的ACR更高（男性 - 3 mg/g 对 6.1 mg/g 对 8.9 mg/g，p = 0.018；女性 - 2.1 mg/g 对 6.7 mg/g 对 9.1 mg/g，p = 0.03）。在单变量分析中，肥胖男性的ACR与脂联素（r = -0.43，p = 0.021）和收缩压（r = 0.51，p = 0.006）相关，非肥胖男性的ACR与收缩压相关（r = 0.39，p = 0.041）。在女性中，收缩压是肥胖（r = 0.49，p = 0.022）和非肥胖受试者（r = 0.42，p = 0.04）中ACR的唯一决定因素。