Department. of Endocrinology, Diabetology, and Isotope Treatment, Wroclaw Medical University, Wybrzeze L. Pasteura 4, 50-367 Wrocław, Poland.
Maturitas. 2010 Mar;65(3):272-5. doi: 10.1016/j.maturitas.2009.11.008. Epub 2009 Dec 9.
A proposed missing link between obesity and metabolic disturbances is adiponectin, an adipocyte-derived peptide. Adiponectin is a potent antidiabetic hormone and seems to have a beneficial influence on lipid profile as well. The need to explain the complex physiological roles of this hormone prompted the authors to study the relationship between adiponectin level and obesity - related abnormalities in a homogenous population of postmenopausal women.
The study involved 272 postmenopausal women aged 50-60 years. Invitations to participate in the study were sent to 4000 randomly chosen women from the Wroclaw city population fulfilling the age criterion. A telephone questionnaire was administered to the group of 1731 women who responded to the invitation and then subjects for the study were selected. Main outcome measures anthropometrical measurements of body fat tissue content and fat tissue distribution assessment were carried out in all the women. Moreover, serum concentrations of adiponectin, glucose, total cholesterol, HDL cholesterol, triglycerides and insulin were measured.
The most frequent (76%) phenotype among the investigated women was obesity (BMI >25) with abnormal (=80cm) waist circumference (OAW), Obesity with normal (<80cm) waist (ONW) and normal weight with abnormal waist (NOAW) were observed in only 5% and 14% of the women, respectively. Non-obese women with normal waist (NONW) were noted in only 5% of the subjects. Serum adiponectin levels in both groups of non-obese women (NOAW and NONW) were significantly higher (p<0.05) than in the women with obesity or overweight and abnormal waist circumference (OAW group). Adiponectin levels in the women with obesity or overweight and normal waist (ONW) were also higher than in the OAW group; however, this difference was not statistically significant (p=0.05). In all the women, serum adiponectin level correlated negatively with BMI (r=-0.34, p=0.0001), total fat (r=-0.28, p=0.0001), android fat deposit (r=-0.23, p=0.0001), waist circumference (r=-0.33, p=0.0001), glucose (r=-0.27, p=0.0001), triglycerides (r=-0.34, p=0.0001), and FIRI (r=-0.34, p=0.0001) and positively with the gynoid/android fat deposit ratio (r=0.28, p=0.0001) and HDL cholesterol (r=0.36, p=0.0001).
These results confirm that adiponectin could be a marker of the development of menopausal insulin resistance syndrome.
肥胖与代谢紊乱之间的一个被提议的缺失环节是脂联素，一种脂肪细胞衍生的肽。脂联素是一种有效的抗糖尿病激素，似乎对脂质谱也有有益的影响。解释这种激素复杂的生理作用的需要促使作者在绝经后妇女同质人群中研究脂联素水平与肥胖相关异常之间的关系。
该研究涉及 272 名 50-60 岁的绝经后妇女。邀请了 4000 名随机选择的符合年龄标准的弗罗茨瓦夫市符合条件的妇女参加这项研究。对回应邀请的 1731 名妇女进行了电话问卷调查，然后选择了研究对象。主要观察指标对所有妇女进行身体脂肪组织含量的人体测量学测量和脂肪组织分布评估。此外，还测量了血清脂联素、葡萄糖、总胆固醇、高密度脂蛋白胆固醇、甘油三酯和胰岛素的浓度。
在所研究的妇女中，最常见的表型（76%）是肥胖（BMI>25）伴异常（=80cm）腰围（OAW），仅 5%和 14%的妇女分别为肥胖伴正常（<80cm）腰围（ONW）和正常体重伴异常腰围（NOAW）。仅 5%的受试者为非肥胖伴正常腰围（NONW）。两组非肥胖妇女（NOAW 和 NONW）的血清脂联素水平均显著升高（p<0.05）高于肥胖或超重伴异常腰围（OAW 组）的妇女。肥胖或超重伴正常腰围（ONW）的妇女的脂联素水平也高于 OAW 组；然而，这种差异没有统计学意义（p=0.05）。在所有妇女中，血清脂联素水平与 BMI（r=-0.34，p=0.0001）、总脂肪（r=-0.28，p=0.0001）、安卓脂肪沉积（r=-0.23，p=0.0001）、腰围（r=-0.33，p=0.0001）、葡萄糖（r=-0.27，p=0.0001）、甘油三酯（r=-0.34，p=0.0001）和 FIRI（r=-0.34，p=0.0001）呈负相关，与女性化/安卓脂肪沉积比（r=0.28，p=0.0001）和高密度脂蛋白胆固醇（r=0.36，p=0.0001）呈正相关。
这些结果证实，脂联素可能是绝经后胰岛素抵抗综合征发展的标志物。
