Gelman M L, Frazier C H, Chandler H P
J Bone Joint Surg Am. 1979 Jul;61(5):657-60.
Eight of forty-one patients undergoing total hip replacement experienced acute but not fatal renal failure postoperatively. All forty-one patients received transfusions of frozen blood and albumin and their wounds were irrigated with a bacitracin-neomycin-polymyxin solution. All subsequently had some relative hypotension. None of a second, prospective group of fifty-five patients who received the transfusion of albumin, but not frozen blood or the bacitracin-neomycin-polymyxin irrigant, had renal failure. The incidence of hypotension in this group was comparable to that in the first group, yet no cases of renal failure were seen. We therefore recommend that the combination of frozen blood and potentially nephrotoxic drugs be avoided in patients undergoing total hip replacement.
41例接受全髋关节置换术的患者中有8例术后出现急性但非致命性肾衰竭。所有41例患者均接受了冷冻血液和白蛋白输血，并用杆菌肽-新霉素-多粘菌素溶液冲洗伤口。所有患者随后均出现了一定程度的相对低血压。在第二组55例前瞻性患者中，他们接受了白蛋白输血，但未接受冷冻血液或杆菌肽-新霉素-多粘菌素冲洗液，无一例出现肾衰竭。该组低血压的发生率与第一组相当，但未见肾衰竭病例。因此，我们建议在接受全髋关节置换术的患者中避免同时使用冷冻血液和具有潜在肾毒性的药物。
