From the Department of Medicine, Howard University College of Medicine.
Design, Biostatistics & Population Studies, Georgetown-Howard Universities Center for Clinical & Translational Research, Howard University College of Medicine, Washington, DC.
J Clin Hypertens (Greenwich). 2012 Feb;14(2):92-96. doi: 10.1111/j.1751-7176.2011.00565.x. Epub 2011 Dec 7.
Obesity has become one of the leading public health concerns in the United States and worldwide. While obesity is associated with the metabolic syndrome, some obese individuals do not possess the constellation of the metabolic abnormalities and are referred to as metabolically healthy but obese (MHO) persons. Limited data exist on the prevalence and characteristics of the MHO in African Americans. The authors studied 126 obese African Americans and defined the MHO phenotype as an individual with a body mass index ≥30 kg/m(2) , high-density lipoprotein cholesterol ≥40 mg/dL, absence of type 2 diabetes mellitus, and absence of arterial hypertension. The correlates of the MHO phenotype with anthropometrical and metabolic indices were examined, as well as the effect of age on these correlates. Results showed that 36 (28.5%) of the individuals were identified with the MHO phenotype. Waist circumference (WC) and waist-to-hip ratio (WHR) were significantly lower (P<.05) in MHO than in non-MHO patients. While there were significant lower levels of low-density lipoprotein and triglycerides in MHO among patients younger than 40 years, the significance was lost among patients 40 years or older. This study indicates that increased WC and WHR may be early premetabolic syndrome markers in obese individuals and should warrant aggressive risk factor reduction therapy to prevent future development of related cardiovascular conditions.
肥胖已成为美国和全球主要的公共卫生关注点之一。尽管肥胖与代谢综合征有关，但有些肥胖个体并没有出现代谢异常的综合征，被称为代谢健康但肥胖（MHO）人群。关于非裔美国人中 MHO 的患病率和特征，数据有限。作者研究了 126 名肥胖的非裔美国人，并将 MHO 表型定义为体重指数≥30kg/m(2)、高密度脂蛋白胆固醇≥40mg/dL、无 2 型糖尿病和无动脉高血压的个体。研究了 MHO 表型与人体测量和代谢指标的相关性，以及年龄对这些相关性的影响。结果显示，36 名（28.5%）个体被确定为 MHO 表型。与非 MHO 患者相比，MHO 患者的腰围（WC）和腰臀比（WHR）显著更低（P<.05）。虽然在 40 岁以下的 MHO 患者中，低密度脂蛋白和甘油三酯水平显著较低，但在 40 岁及以上的患者中，这种差异就不明显了。本研究表明，WC 和 WHR 的增加可能是非代谢综合征肥胖个体早期的代谢前综合征标志物，应采取积极的危险因素降低治疗，以预防相关心血管疾病的发生。
