Department of Neurology, Korea University College of Medicine, Guro-gu, Seoul, Korea.
J Stroke Cerebrovasc Dis. 2012 Apr;21(3):181-6. doi: 10.1016/j.jstrokecerebrovasdis.2010.06.002. Epub 2012 Jan 24.
Although the association between elevated C-reactive protein (CRP) level and long-term outcome after ischemic stroke is well known, the association between CRP and early neurologic deterioration (END) has not yet been thoroughly studied. We investigated the impact of CRP on END in patients with acute ischemic stroke. From a prospectively collected, multicenter stroke registry, 428 patients with acute ischemic stroke diagnosed within 24 hours of onset were enrolled in the study. Patients with hemorrhagic stroke, transient ischemic attack, and thrombolysis were excluded. END was defined as a >2-point increase in the National Institutes of Health Stroke Scale score within a 72-hour period. Data considered potentially associated with CRP level and the END were collected. END was observed in 47 patients. CRP level, time before arrival at the hospital, age, female sex, hematocrit, high-density lipoprotein (HDL) cholesterol level, hemoglobin A(1c) level, and internal carotid artery occlusion were significantly associated with END. On logistic regression analysis, CRP level, internal carotid artery occlusion, and HDL cholesterol proved to be independent variables. Our data suggest that CRP level at admission is significantly associated with END in acute ischemic stroke. HDL cholesterol and internal carotid artery occlusion are also associated with END.
虽然已知 C 反应蛋白（CRP）水平升高与缺血性脑卒中后长期预后相关，但 CRP 与早期神经功能恶化（END）的关系尚未得到充分研究。我们研究了 CRP 对急性缺血性脑卒中患者 END 的影响。本研究纳入了在发病后 24 小时内确诊的 428 例急性缺血性脑卒中患者，这些患者来自前瞻性收集的多中心脑卒中登记处。排除了出血性脑卒中、短暂性脑缺血发作和溶栓治疗的患者。END 定义为在 72 小时内 NIHSS 评分增加>2 分。收集了与 CRP 水平和 END 相关的潜在数据。47 例患者发生 END。CRP 水平、到达医院前的时间、年龄、女性、红细胞压积、高密度脂蛋白（HDL）胆固醇水平、血红蛋白 A1c 水平和颈内动脉闭塞与 END 显著相关。在逻辑回归分析中，CRP 水平、颈内动脉闭塞和 HDL 胆固醇被证明是独立的变量。我们的数据表明，入院时的 CRP 水平与急性缺血性脑卒中的 END 显著相关。HDL 胆固醇和颈内动脉闭塞也与 END 相关。
