School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210029, People's Republic of China.
J Pharm Biomed Anal. 2012 Mar 25;62:187-90. doi: 10.1016/j.jpba.2011.12.016. Epub 2012 Jan 5.
Ultra performance liquid chromatography/quadrupole-time-of-flight mass spectrometry (UPLC/QTOF MS) was employed to investigate the in vivo metabolism of liguzinediol. Urine, bile, feces and plasma samples were collected after intravenous administration of 10mg/kg liguzinediol to healthy rats. Altogether seven metabolites were detected and tentatively identified based on the characteristics of their protonated ions. The metabolites were mainly transformed by four main metabolic pathways including oxidation, sulfation, glycine conjugation and glucuronidation.
超高效液相色谱/四极杆飞行时间质谱（UPLC/QTOF MS）被用于研究体内利古津二醇的代谢。静脉给予健康大鼠 10mg/kg 利古津二醇后，收集尿液、胆汁、粪便和血浆样品。共检测到 7 种代谢物，并根据其质子化离子的特征初步鉴定。代谢物主要通过氧化、硫酸化、甘氨酸结合和葡萄糖醛酸化四种主要代谢途径转化。
