大鼠可卡因和水强化物反应的.session 间累进比率表现。
Between-session progressive ratio performance in rats responding for cocaine and water reinforcers.
机构信息
Research Institute on Addictions, University at Buffalo, 1021 Main St, Buffalo, NY 14203, USA.
出版信息
Psychopharmacology (Berl). 2012 Jul;222(2):215-23. doi: 10.1007/s00213-012-2637-9. Epub 2012 Jan 27.
RATIONALE
A between-session progressive ratio (BtwPR) procedure was tested in rats responding for cocaine and water reinforcers.
OBJECTIVES
Experiment 1 evaluated the sensitivity of the BtwPR procedure to the magnitude of cocaine and water reinforcers. Experiment 2 compared BtwPR performance to within-session progressive ratio (WinPR) performance.
METHODS
In experiment 1, rats were tested on a BtwPR procedure with three doses of cocaine (0.1, 0.3, and 1.0 mg/kg/inf) or volumes of water (0.01, 0.03, and 0.1 mL/reinforcer). BtwPR test sessions began with a seeking phase, during which the animal is required to complete a fixed ratio in order to initiate a 2-h consumption phase, where the reinforcer was available according to a fixed ratio 1 (FR1) schedule. Failure to complete the seeking ratio, which was increased after each test session, determined the breakpoint (BP). In experiment 2, the same BtwPR procedure was used except that the consumption phase was a WinPR schedule of reinforcement for cocaine (1.0 mg/kg/inf) or water (0.1 mL) reinforcers.
RESULTS AND CONCLUSIONS
BtwPR BPs increased as a function of the magnitude of both cocaine and water reinforcers. The BtwPR produced smaller BPs than the WinPR for cocaine reinforcers. In contrast, the BtwPR produced larger BPs than the WinPR for water reinforcers. One possible explanation is that priming and response activating effects of the cocaine reinforcer increased the WinPR BP. BtwPR and WinPR procedures may measure different aspects of drug-seeking.
原理
在可卡因和水强化物的大鼠反应中测试了会话间递增比率（BtwPR）程序。
目的
实验 1 评估了 BtwPR 程序对可卡因和水强化物的强度的敏感性。实验 2 将 BtwPR 性能与会话内递增比率（WinPR）性能进行比较。
方法
在实验 1 中，大鼠在 BtwPR 程序中接受三种剂量的可卡因（0.1、0.3 和 1.0mg/kg/inf）或水（0.01、0.03 和 0.1mL/强化物）的测试。BtwPR 测试会话开始时是寻求阶段，在此期间，动物需要完成一个固定的比率，以启动 2 小时的消耗阶段，在消耗阶段，根据固定比率 1（FR1）时间表提供强化物。如果不能完成寻求比率（每个测试会话后都会增加），则确定断点（BP）。在实验 2 中，使用了相同的 BtwPR 程序，只是消耗阶段是可卡因（1.0mg/kg/inf）或水（0.1mL）强化物的 WinPR 强化时间表。
结果与结论
BtwPR 的 BP 随着可卡因和水强化物的强度而增加。BtwPR 产生的 BP 比可卡因强化物的 WinPR 小。相比之下，BtwPR 产生的 BP 比水强化物的 WinPR 大。一种可能的解释是，可卡因强化物的启动和反应激活作用增加了 WinPR 的 BP。BtwPR 和 WinPR 程序可能测量了不同的觅药方面。
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