Systems and Structural Biology Center, RIKEN, Tsurumi, Japan.
Wiley Interdiscip Rev RNA. 2012 Mar-Apr;3(2):229-46. doi: 10.1002/wrna.1107. Epub 2012 Jan 25.
'RNA recognition motifs (RRMs)' are common domain-folds composed of 80-90 amino-acid residues in eukaryotes, and have been identified in many cellular proteins. At first they were known as RNA binding domains. Through discoveries over the past 20 years, however, the RRMs have been shown to exhibit versatile molecular recognition activities and to behave as molecular Lego building blocks to construct biological systems. Novel RNA/protein recognition modes by RRMs are being identified, and more information about the molecular recognition by RRMs is becoming available. These RNA/protein recognition modes are strongly correlated with their biological significance. In this review, we would like to survey the recent progress on these versatile molecular recognition modules.
'RNA 识别基序 (RRMs)' 是真核生物中常见的由 80-90 个氨基酸残基组成的结构域折叠，已在许多细胞蛋白中被鉴定。起初，它们被称为 RNA 结合结构域。然而，在过去的 20 年中，通过发现，RRMs 表现出多种多样的分子识别活性，并作为分子乐高积木来构建生物系统。新型的 RRMs 的 RNA/蛋白质识别模式正在被鉴定，并且关于 RRMs 的分子识别的更多信息正在变得可用。这些 RNA/蛋白质识别模式与它们的生物学意义密切相关。在这篇综述中，我们将调查这些多功能分子识别模块的最新进展。
