• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

正常滑膜。

The normal synovium.

作者信息

Smith Malcolm D

机构信息

Rheumatology Unit, Repatriation General Hospital, Daws Road, Daw Park, South Australia, SA 5041, Australia.

出版信息

Open Rheumatol J. 2011;5:100-6. doi: 10.2174/1874312901105010100. Epub 2011 Dec 30.

DOI:10.2174/1874312901105010100
PMID:22279508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3263506/
Abstract

This paper describes the structure and function of the normal synovium including the cellular content, nerve and vascular supply and how normal synovium maintains homeostasis within the joint. It is important to understand normal synovium before appreciating the changes that occur in the synovial membrane which leads to the pathology seen in inflammatory arthritides such as Rheumatoid Arthritis.

摘要

本文描述了正常滑膜的结构和功能,包括细胞成分、神经和血管供应,以及正常滑膜如何在关节内维持稳态。在了解滑膜发生的导致类风湿关节炎等炎性关节炎中所见病理变化之前,了解正常滑膜很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/08954d85fda6/TORJ-5-100_F14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/6dee314e748b/TORJ-5-100_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/f8c7bac38b91/TORJ-5-100_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/42ab6fc38a16/TORJ-5-100_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/73252c1a16a2/TORJ-5-100_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/ae3348b376fd/TORJ-5-100_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/2205c1212c1c/TORJ-5-100_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/5a631ca37c75/TORJ-5-100_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/c817133a8df4/TORJ-5-100_F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/72bc950b427e/TORJ-5-100_F9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/58ffbb715898/TORJ-5-100_F10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/e3ec585368d9/TORJ-5-100_F11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/642fdc49bb20/TORJ-5-100_F12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/db2e09cb00df/TORJ-5-100_F13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/08954d85fda6/TORJ-5-100_F14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/6dee314e748b/TORJ-5-100_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/f8c7bac38b91/TORJ-5-100_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/42ab6fc38a16/TORJ-5-100_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/73252c1a16a2/TORJ-5-100_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/ae3348b376fd/TORJ-5-100_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/2205c1212c1c/TORJ-5-100_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/5a631ca37c75/TORJ-5-100_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/c817133a8df4/TORJ-5-100_F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/72bc950b427e/TORJ-5-100_F9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/58ffbb715898/TORJ-5-100_F10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/e3ec585368d9/TORJ-5-100_F11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/642fdc49bb20/TORJ-5-100_F12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/db2e09cb00df/TORJ-5-100_F13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97aa/3263506/08954d85fda6/TORJ-5-100_F14.jpg

相似文献

1
The normal synovium.正常滑膜。
Open Rheumatol J. 2011;5:100-6. doi: 10.2174/1874312901105010100. Epub 2011 Dec 30.
2
Immunolocalization of inducible nitric oxide synthase in synovium and cartilage in rheumatoid arthritis and osteoarthritis.类风湿关节炎和骨关节炎中滑膜及软骨组织中诱导型一氧化氮合酶的免疫定位
Br J Rheumatol. 1997 Jun;36(6):651-5. doi: 10.1093/rheumatology/36.6.651.
3
Monocyte chemoattractant protein-1 (MCP-1) in inflammatory joint diseases and its involvement in the cytokine network of rheumatoid synovium.炎症性关节疾病中的单核细胞趋化蛋白-1(MCP-1)及其在类风湿滑膜细胞因子网络中的作用。
Clin Immunol Immunopathol. 1993 Oct;69(1):83-91. doi: 10.1006/clin.1993.1153.
4
Synovial biology and T cells in rheumatoid arthritis.类风湿关节炎中的滑膜生物学与T细胞
Pathophysiology. 2005 Oct;12(3):183-9. doi: 10.1016/j.pathophys.2005.07.005.
5
The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium.血管细胞黏附分子1/极迟活化抗原4在类风湿关节炎滑膜内皮祖细胞募集中的作用
Arthritis Rheum. 2007 Jun;56(6):1817-26. doi: 10.1002/art.22706.
6
Expression analysis of three isoforms of hyaluronan synthase and hyaluronidase in the synovium of knees in osteoarthritis and rheumatoid arthritis by quantitative real-time reverse transcriptase polymerase chain reaction.通过定量实时逆转录聚合酶链反应分析骨关节炎和类风湿关节炎膝关节滑膜中三种透明质酸合酶和透明质酸酶同工型的表达
Arthritis Res Ther. 2004;6(6):R514-20. doi: 10.1186/ar1223. Epub 2004 Sep 22.
7
Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment.银屑病关节炎患者滑膜中细胞浸润以及滑膜炎症和关节破坏介质表达的详细分析:对治疗的启示
Ann Rheum Dis. 2006 Dec;65(12):1551-7. doi: 10.1136/ard.2005.050963. Epub 2006 May 25.
8
[Fibronectin in the synovium and synovial fluid in rheumatoid arthritis and in osteoarthritis].[类风湿关节炎和骨关节炎中滑膜及滑液中的纤连蛋白]
Nihon Seikeigeka Gakkai Zasshi. 1994 Apr;68(4):172-83.
9
The innervation of synovium of human osteoarthritic joints in comparison with normal rat and sheep synovium.人骨性关节炎关节滑膜的神经支配与正常大鼠和绵羊滑膜的比较。
Osteoarthritis Cartilage. 2013 Sep;21(9):1383-91. doi: 10.1016/j.joca.2013.06.018.
10
Expression of p53 protein in rheumatoid arthritis synovium. An immunohistochemical analysis.类风湿关节炎滑膜中p53蛋白的表达。一项免疫组织化学分析。
Korean J Intern Med. 1999 Jan;14(1):59-65. doi: 10.3904/kjim.1999.14.1.59.

引用本文的文献

1
Histopathological evaluation of synovial tissue in advanced osteoarthritis: A retrospective study based on total knee arthroplasty specimens.晚期骨关节炎滑膜组织的组织病理学评估:一项基于全膝关节置换术标本的回顾性研究。
Medicine (Baltimore). 2025 Aug 29;104(35):e44152. doi: 10.1097/MD.0000000000044152.
2
Synovial Organoids and Cell Culture Models: An Ideal Platform for Exploring Traditional Chinese Medicine in Rheumatoid Arthritis.滑膜类器官与细胞培养模型:类风湿关节炎中探索中医药的理想平台
ACS Omega. 2025 Aug 12;10(33):36904-36916. doi: 10.1021/acsomega.5c06035. eCollection 2025 Aug 26.
3
A 2D inflammatory co-culture model for investigating synovial fibroblast and macrophage interactions in rheumatoid arthritis.

本文引用的文献

1
The structure and functions of the synovial membrane.滑膜的结构与功能。
Br Med J. 1950 Jan 14;1(4645):92-5. doi: 10.1136/bmj.1.4645.92.
2
Immunohistochemistry of normal human knee synovium: a quantitative study.正常人膝关节滑膜的免疫组织化学:一项定量研究。
Ann Rheum Dis. 2004 Jul;63(7):785-90. doi: 10.1136/ard.2003.013383.
3
Distribution of lymphatic vessels in normal and arthritic human synovial tissues.正常及关节炎患者人类滑膜组织中淋巴管的分布
一种用于研究类风湿关节炎中滑膜成纤维细胞与巨噬细胞相互作用的二维炎症共培养模型。
Sci Rep. 2025 Aug 17;15(1):30105. doi: 10.1038/s41598-025-16007-3.
4
Peripheral neuronal sensitization and neurovascular remodelling in osteoarthritis pain.骨关节炎疼痛中的外周神经元致敏和神经血管重塑。
Nat Rev Rheumatol. 2025 Aug 12. doi: 10.1038/s41584-025-01280-3.
5
Nucleic acid aptamers in orthopedic diseases: promising therapeutic agents for bone disorders.骨科疾病中的核酸适配体:治疗骨病的潜在治疗剂。
Bone Res. 2025 Jul 24;13(1):71. doi: 10.1038/s41413-025-00447-8.
6
Oxidative Stress, MicroRNAs, and Long Non-Coding RNAs in Osteoarthritis Pathogenesis: Cross-Talk and Molecular Mechanisms Involved.骨关节炎发病机制中的氧化应激、微小RNA和长链非编码RNA:相互作用及相关分子机制
Int J Mol Sci. 2025 Jul 3;26(13):6428. doi: 10.3390/ijms26136428.
7
Unveiling the Therapeutic Potential: Targeting Fibroblast-like Synoviocytes in Rheumatoid Arthritis.揭示治疗潜力:靶向类风湿关节炎中的成纤维细胞样滑膜细胞
Expert Rev Mol Med. 2025 Jun 5;27:e18. doi: 10.1017/erm.2025.11.
8
The ontogeny of synovial tissue macrophages.滑膜组织巨噬细胞的个体发生。
Front Immunol. 2025 May 20;16:1603473. doi: 10.3389/fimmu.2025.1603473. eCollection 2025.
9
Fibroblasts in immune responses, inflammatory diseases and therapeutic implications.成纤维细胞在免疫反应、炎症性疾病及治疗中的意义。
Nat Rev Rheumatol. 2025 May 14. doi: 10.1038/s41584-025-01259-0.
10
Perivascular RELMα-positive synovial macrophages recruit monocytes at the onset of inflammatory arthritis.血管周围富含半胱氨酸的酸性分泌蛋白α阳性滑膜巨噬细胞在炎性关节炎发病时募集单核细胞。
Front Immunol. 2025 Apr 17;16:1567661. doi: 10.3389/fimmu.2025.1567661. eCollection 2025.
Ann Rheum Dis. 2003 Dec;62(12):1227-9. doi: 10.1136/ard.2003.005876.
4
ULTRASTRUCTURE OF THE JOINT CAPSULE IN THE RAT: PRESENCE OF TWO KINDS OF CAPILLARIES.大鼠关节囊的超微结构:两种毛细血管的存在。
Nature. 1964 May 30;202:920-1. doi: 10.1038/202920b0.
5
Electron microscopy of the human synovial membrane.人体滑膜的电子显微镜检查
J Cell Biol. 1962 Aug;14(2):207-20. doi: 10.1083/jcb.14.2.207.
6
Microarchitecture and protective mechanisms in synovial tissue from clinically and arthroscopically normal knee joints.临床及关节镜检查正常膝关节滑膜组织的微观结构与保护机制
Ann Rheum Dis. 2003 Apr;62(4):303-7. doi: 10.1136/ard.62.4.303.
7
Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets.骨关节炎,一种炎症性疾病:对新治疗靶点选择的潜在影响。
Arthritis Rheum. 2001 Jun;44(6):1237-47. doi: 10.1002/1529-0131(200106)44:6<1237::AID-ART214>3.0.CO;2-F.
8
Lubricin is a product of megakaryocyte stimulating factor gene expression by human synovial fibroblasts.润滑素是人类滑膜成纤维细胞中巨核细胞刺激因子基因表达的产物。
J Rheumatol. 2000 Mar;27(3):594-600.
9
Differential distribution of Fc gamma RIIIa in normal human tissues and co-localization with DAF and fibrillin-1: implications for immunological microenvironments.FcγRIIIa在正常人体组织中的差异分布及其与衰变加速因子(DAF)和原纤蛋白-1的共定位:对免疫微环境的影响
Immunology. 1998 May;94(1):56-63. doi: 10.1046/j.1365-2567.1998.00491.x.
10
Fluid movement across synovium in healthy joints: role of synovial fluid macromolecules.健康关节中滑膜的液体流动:滑液大分子的作用。
Ann Rheum Dis. 1995 May;54(5):417-23. doi: 10.1136/ard.54.5.417.