[青海藏族人群中ADH3和ALDH2的基因多态性及其与饮酒行为的关系]
[Genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior].
作者信息
Liu Yan, Li Xingxiang, Wang Chaocai, Zhang Benzhong
机构信息
Department of Toxicology, College of Public Health, Lanzhou University, Lanzhou 730000, China.
出版信息
Wei Sheng Yan Jiu. 2011 Nov;40(6):784-6.
OBJECTIVE
To investigate the genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior.
METHODS
Polymerase chain reaction-restriction fragment length polymorphism ( PCR-RFLP ) technique was used to detect the genotype of ADH3 and ALDH2. Drinking behavior was obtained by questionnaire.
RESULTS
The frequency of ADH32 and ALDH22 alleles in Tibetan population was 7.79% and 22.21% respectively, the frequency of ALDH22 and ADH31 alleles in non-drinkers was higher than that in drinkers, and the frequency of ALDH22 and ADH31 alleles in risk drinkers was lower than that in safe drinkers.
CONCLUSION
ADH3 and ALDH2 are associated with drinking behavior in male Tibetan population.
目的
探讨青海藏族人群乙醇脱氢酶3（ADH3）和乙醛脱氢酶2（ALDH2）基因多态性及其与饮酒行为的关系。
方法
采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测ADH3和ALDH2基因型。通过问卷调查获取饮酒行为信息。
结果
藏族人群中ADH32和ALDH22等位基因频率分别为7.79%和22.21%，非饮酒者中ALDH22和ADH31等位基因频率高于饮酒者，危险饮酒者中ALDH22和ADH31等位基因频率低于安全饮酒者。
结论
ADH3和ALDH2与藏族男性饮酒行为有关。
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