[高血压性脑血管疾病患者的血清免疫生化标志物]

[Serum immunoboichemical markers in patients suffered with hypertension-induced cerebrovascular diseases].

作者信息

Elistratova E I, Gruden' M A, Davydova T V, Sherstnev V V

出版信息

Patol Fiziol Eksp Ter. 2011 Jul-Sep(3):25-8.

Abstract

Complex evaluation neurotrophic protein S100b, differentiation factor HLDF, idio-and antiidiotypic antibodies against these proteins in patient sera with hypertension-induced cerebrovascular disorders was performed by ELISA. In patients with essential hypertension, cerebral hypertensive crisis and ischemic stroke S100b and anti-S100b concentration was found to be higher, whereas HLDF and anti-HLDF ones were lower compared with control. Different dynamics of S100b, HLDF content and antibody level was shown within 21 days of observation. These findings may be useful in further diagnostic and prognostic studies of hypertension-induced cerebrovascular disorders.

摘要

采用酶联免疫吸附测定法（ELISA）对高血压性脑血管疾病患者血清中的复合评估神经营养蛋白S100b、分化因子HLDF以及针对这些蛋白的独特型和抗独特型抗体进行检测。结果发现，与对照组相比，原发性高血压、高血压脑病和缺血性中风患者的S100b和抗S100b浓度较高，而HLDF和抗HLDF浓度较低。在观察的21天内，S100b、HLDF含量及抗体水平呈现出不同的动态变化。这些发现可能有助于高血压性脑血管疾病的进一步诊断和预后研究。