Eigenmann P A, Hauser C, Brüggen M-C
Service d'allergologie pédiatrique, Hôpital des enfants, HUG, Genève.
Rev Med Suisse. 2011 Dec 14;7(321):2453-6.
Atopic dermatitis (AD) is a chronic inflammatory skin disorder and the most frequent skin disease in children. Skin barrier defects play a crucial role in its pathogenesis. 50% of patients suffering from AD present mutations in the filaggrin gene, coding for a key protein of the upper layer of the skin. However these mutations alone are not sufficient for disease development, suggesting that environmental factors are also of great importance in the genesis of AD. In particular skin infections frequently provoke clinical exacerbations in patients suffering from AD. New insights into skin barrier dysfunctions have facilitated the development of drugs targeting the sustainable restitution of the skin's physiologic function. These agents could modify the pharmacological approach of AD treatments in the future.
特应性皮炎（AD）是一种慢性炎症性皮肤病，也是儿童中最常见的皮肤病。皮肤屏障缺陷在其发病机制中起关键作用。50%的AD患者存在丝聚合蛋白基因突变，该基因编码皮肤上层的一种关键蛋白。然而，仅这些突变不足以引发疾病，这表明环境因素在AD的发生中也非常重要。特别是皮肤感染经常会引发AD患者的临床病情加重。对皮肤屏障功能障碍的新认识促进了旨在可持续恢复皮肤生理功能的药物的开发。这些药物可能会在未来改变AD的药物治疗方法。
