Kasperska-Zajac Alicja, Koczy-Baron Ewa
Slaski Uniwersytet Medyczny w Katowicach, Katedra i Klinika Chorób Wewnetrznych, Alergologii i Immunologii Klinicznej.
Pol Merkur Lekarski. 2011 Nov;31(185):309-12.
Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease, pathogenesis of which has not been fully recognised yet. Th1/ Th2 cells dysregulation, skin barrier defects and influence of environmental factors, including allergens and microbes seem to play an important role in the disease. Apart from infiltration from the inflammatory cells, the histological picture of skin lesions occurring in the course of the disease shows some oedema as well as the reparative processes appearing as fibrosis and angiogenesis which points to participation of factors contributing to endothelial permeability and the growth in pathomechanism of the disease. The vascular endothelial growth factor - VEGF, is a multifunctional proinflammatory cytokine which, 50 000 times stronger than histamine, increases the vascular endothelial permeability and plays the major role in angiogenesis. The role of such cytokine in the acute and chronic inflammatory response has been poorly recognised. Overproduction of VEGF in the skin and release into the bloodstream of patients suffering from AD has been pointed to, which suggest some role of this cytokine in the pathomechanism of AD.
特应性皮炎（AD）是一种慢性复发性炎症性皮肤病，其发病机制尚未完全明确。Th1/Th2细胞失调、皮肤屏障缺陷以及包括过敏原和微生物在内的环境因素的影响似乎在该疾病中起重要作用。除了炎症细胞浸润外，疾病过程中出现的皮肤病变的组织学表现显示出一些水肿以及表现为纤维化和血管生成的修复过程，这表明促成内皮通透性和生长的因素参与了疾病的发病机制。血管内皮生长因子-VEGF是一种多功能促炎细胞因子，其作用比组胺强50000倍，可增加血管内皮通透性，并在血管生成中起主要作用。这种细胞因子在急性和慢性炎症反应中的作用尚未得到充分认识。有人指出，AD患者皮肤中VEGF过度产生并释放到血液中，这表明该细胞因子在AD发病机制中发挥了一定作用。
