Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
J Interferon Cytokine Res. 2012 Mar;32(3):103-10. doi: 10.1089/jir.2011.0099. Epub 2012 Jan 26.
The signal transducer and activator of transcription-2 (STAT2) was discovered as a cellular component of the DNA binding complex known as interferon (IFN) stimulated gene factor-3. Numerous studies have confirmed that STAT2 operates as a positive regulator in the transcriptional activation response elicited by IFNs. In this article, we highlight the progress made in elucidating the pivotal role of STAT2 in driving the expression of IFN-induced genes, innate antiviral immunity, apoptosis, and cancer. A better understanding of the functional role of STAT2 in the IFN response and how STAT2 is regulated will uncover new clues to its role in diseases.
信号转导子和转录激活子 2（STAT2）最初被发现是一种细胞成分，存在于称为干扰素（IFN）刺激基因因子-3 的 DNA 结合复合物中。大量研究证实，STAT2 在 IFNs 诱导的转录激活反应中作为一个正调控因子发挥作用。在本文中，我们重点阐述了 STAT2 在驱动 IFN 诱导基因、先天抗病毒免疫、细胞凋亡和癌症表达方面的关键作用的研究进展。更好地了解 STAT2 在 IFN 反应中的功能作用以及 STAT2 是如何被调控的，将为其在疾病中的作用提供新的线索。
