Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030-4009, USA.
Clin Colorectal Cancer. 2012 Sep;11(3):191-4. doi: 10.1016/j.clcc.2011.12.003. Epub 2012 Jan 26.
The purpose of this study was to determine the outcome of patients with colorectal cancer metastatic to the ovary and the impact of surgical oophorectomy on the outcome.
We conducted a retrospective evaluation of patients with metastatic colorectal cancer to the ovary. Of 3776 female patients with colorectal cancer seen at MD Anderson from 2001-2008, 110 (2.9%) were identified as having metastases to the ovary. The Kaplan-Meier method and log-rank test were used to examine the survival functions.
Seventy-one patients (64.5%) had disease metastatic to the ovary at the time of initial presentation; in 39 patients (35.5%) the ovaries were a site of relapse after previous curative colorectal surgical resection. Patients who presented with ovarian relapse after previous colorectal surgery and who underwent oophorectomy had a median survival of 50 months compared with 12 months for those who did not (P < .0001). Patients with metastatic disease at the time of presentation who underwent oophorectomy had a median survival of 39.4 months vs. 18.2 months for those who did not.
This retrospective analysis suggests that women with metastatic colorectal cancer metastatic to the ovary may derive a survival benefit from palliative oophorectomy.
本研究旨在确定卵巢转移性结直肠癌患者的结局以及手术卵巢切除术对结局的影响。
我们对卵巢转移性结直肠癌患者进行了回顾性评估。在 2001 年至 2008 年间在 MD 安德森癌症中心就诊的 3776 名女性结直肠癌患者中，有 110 名（2.9%）被确定为卵巢转移。采用 Kaplan-Meier 方法和对数秩检验来检验生存函数。
71 名患者（64.5%）在初始就诊时就患有卵巢转移性疾病；在 39 名患者（35.5%）中，卵巢是先前根治性结直肠手术切除后复发的部位。与未行卵巢切除术的患者相比，先前行结直肠手术切除且卵巢复发后行卵巢切除术的患者中位生存期为 50 个月，而未行卵巢切除术的患者中位生存期为 12 个月（P<0.0001）。初始就诊时患有转移性疾病且行卵巢切除术的患者中位生存期为 39.4 个月，而未行卵巢切除术的患者中位生存期为 18.2 个月。
这项回顾性分析表明，卵巢转移性结直肠癌女性患者可能从姑息性卵巢切除术获得生存获益。
