Department of Urology, IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
Eur Urol. 2012 May;61(5):908-13. doi: 10.1016/j.eururo.2012.01.018. Epub 2012 Jan 20.
Narrow band imaging (NBI) is an optical enhancement technology that filters white light into two bandwidths of illumination centered on 415nm (blue) and 540nm (green). NBI cystoscopy can increase bladder cancer (BCa) visualization and detection at the time of transurethral resection (TUR). NBI may therefore reduce subsequent relapse following TUR.
Assess the impact of NBI modality on 1-yr non-muscle-invasive BCa (NMIBC) recurrence risk.
DESIGN, SETTING, AND PARTICIPANTS: Consecutive patients with overt or suspected BCa were included in a prospective study powered to test a 10% difference in 1-yr recurrence risk in favor of cases submitted to NBI TUR. Excluding patients with muscle-invasive BCa, negative pathologic examination, or without follow-up, the study population was composed of 148 subjects randomized from August 2009 to September 2010 to NBI TUR (76 cases) or white light (WL) TUR (72 cases).
TUR was performed in NBI or standard WL modality.
The 1-yr recurrence risks in NBI or WL TUR groups were compared using odds ratio (OR) point and interval estimates derived from logistic regression modeling.
The 1-yr recurrence-risk was 25 of 76 patients (32.9%) in the NBI and 37 of 72 patients (51.4%) in the WL group (OR=0.62; p=0.0141). Simple and multiple logistic regression analyses provided similar OR points and interval estimates.
TUR performed in the NBI modality reduces the recurrence risk of NMIBC by at least 10% at 1 yr.
窄带成像（NBI）是一种光学增强技术，它将白光过滤成两个带宽的照明，分别集中在 415nm（蓝色）和 540nm（绿色）。NBI 膀胱镜检查可以增加经尿道切除（TUR）时膀胱癌（BCa）的可视化和检测。因此，NBI 可能会降低 TUR 后复发的风险。
评估 NBI 模式对 1 年非肌层浸润性膀胱癌（NMIBC）复发风险的影响。
设计、地点和参与者：连续纳入显性或疑似膀胱癌患者的前瞻性研究，旨在测试 NBI TUR 组在 1 年内复发风险降低 10%的效果。排除肌层浸润性膀胱癌、阴性病理检查或无随访的患者，研究人群由 2009 年 8 月至 2010 年 9 月间随机分为 NBI TUR 组（76 例）或白光（WL） TUR 组（72 例）的 148 例患者组成。
在 NBI 或标准 WL 模式下进行 TUR。
采用 logistic 回归模型，通过比值比（OR）点和区间估计值比较 NBI 或 WL TUR 组的 1 年复发风险。
NBI 组 1 年复发风险为 76 例患者中的 25 例（32.9%），WL 组为 72 例患者中的 37 例（51.4%）（OR=0.62；p=0.0141）。简单和多元逻辑回归分析提供了相似的 OR 点和区间估计。
NBI 模式下的 TUR 可将 NMIBC 的复发风险降低至少 10%，在 1 年内。
