Department of Psychology and Collaborative Neuroscience Program, University of Guelph, 50 Stone Road, Guelph, ON N1G 2W1, Canada.
Neuropharmacology. 2012 Apr;62(5-6):2096-105. doi: 10.1016/j.neuropharm.2012.01.008. Epub 2012 Jan 20.
The perirhinal cortex (PRh) and its cholinergic inputs are implicated in object recognition memory. Conversely, the hippocampus (HPC) may be involved in spatial recognition processes that are not essential to the recognition of objects per se. Systemic nicotine has been shown to facilitate both object and spatial memory. The current study compared the roles of perirhinal and hippocampal nicotinic acetylcholine receptors (nAChRs) in object and spatial recognition memory using spontaneous object recognition (SOR) and object-location (OL) tasks for rats. Systemic pre-sample (acquisition) nicotine administration dose-dependently facilitated SOR and OL performance compared to vehicle conditions in which performance was at chance with a 72-h retention delay between the sample and choice phases. Subsequently, pre-sample intra-PRh infusions of nicotine significantly facilitated SOR; somewhat surprisingly, pre-sample intra-HPC nicotine also enhanced object recognition memory. Further experiments indicated facilitative effects on OL performance caused by pre-sample intra-PRh or intra-HPC nicotine administration. These results not only demonstrate that nAChR activation facilitates performance on object recognition and object-location memory tasks, but suggest that these effects can be produced by nAChR action in either PRh or HPC. Thus, although PRh and HPC are not required for OL or SOR task performance, respectively, nAChR-mediated enhancement of neural function in either of these temporal lobe regions appears capable of promoting stronger memory encoding and/or consolidation in either task. These findings further support the supposed interactive relationship between the HPC and PRh in object information processing and highlight the potential therapeutic value of nicotinic receptor activation in amnesic disorders.
眶额皮层（PRh）及其胆碱能输入与物体识别记忆有关。相反，海马体（HPC）可能参与空间识别过程，但这些过程对于物体本身的识别并不是必需的。系统给予尼古丁已被证明可以促进物体和空间记忆。本研究使用大鼠的自发物体识别（SOR）和物体位置（OL）任务，比较了 PRh 和海马体烟碱型乙酰胆碱受体（nAChR）在物体和空间识别记忆中的作用。与在样本和选择阶段之间有 72 小时保留延迟的情况下，表现处于偶然水平的载体条件相比，系统给药前（获得）尼古丁给药剂量依赖性地促进了 SOR 和 OL 表现。随后，PRh 内给予尼古丁预处理显著促进了 SOR；有些令人惊讶的是，HPC 内给予尼古丁预处理也增强了物体识别记忆。进一步的实验表明，PRh 或 HPC 内给予尼古丁预处理会促进 OL 表现。这些结果不仅表明 nAChR 激活促进了物体识别和物体位置记忆任务的表现，而且表明这些效应可以通过 PRh 或 HPC 中的 nAChR 作用产生。因此，尽管 PRh 和 HPC 分别不是 OL 或 SOR 任务表现所必需的，但这些颞叶区域中 nAChR 介导的神经功能增强似乎能够在任一任务中促进更强的记忆编码和/或巩固。这些发现进一步支持了 HPC 和 PRh 在物体信息处理中的相互作用关系，并突出了烟碱受体激活在健忘症中的潜在治疗价值。
