Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Chungcheongbuk-do, Korea.
BMB Rep. 2012 Jan;45(1):47-50. doi: 10.5483/bmbrep.2012.45.1.47.
The International HapMap Project and the Human Genome Diversity Project (HGDP) provide plentiful resources on human genome information to the public. However, this kind of information is limited because of the small sample size in both databases. A Genome-Wide Association Study has been conducted with 8,842 Korean subjects as a part of the Korea Association Resource (KARE) project. In an effort to build a publicly available browsing system for genome data resulted from large scale KARE GWAS, we developed the KARE browser. This browser provides users with a large amount of single nucleotide polymorphisms (SNPs) information comprising 1.5 million SNPs from population-based cohorts of 8,842 samples. KAREBrowser was based on the generic genome browser (GBrowse), a webbased application tool developed for users to navigate and visualize the genomic features and annotations in an interactive manner. All SNP information and related functions are available at the web site http://ksnp.cdc. go.kr/karebrowser/.
国际人类基因组单体型图计划和人类基因组多样性计划为公众提供了大量的人类基因组信息资源。然而，由于这两个数据库的样本量都很小，这种信息是有限的。韩国关联资源（KARE）项目对 8842 名韩国人进行了全基因组关联研究。为了建立一个可公开获取的大规模 KARE GWAS 基因组数据浏览系统，我们开发了 KARE 浏览器。该浏览器为用户提供了大量的单核苷酸多态性（SNP）信息，其中包含来自 8842 个样本的基于人群的 150 万个 SNP。KAREBrowser 是基于通用基因组浏览器（GBrowse）开发的，这是一种基于网络的应用程序工具，用于用户以交互方式导航和可视化基因组特征和注释。所有 SNP 信息和相关功能都可在网站 http://ksnp.cdc.go.kr/karebrowser/上获取。
