Sutphen J L
University of Virginia Health Sciences Center, Charlottesville.
Gastroenterol Clin North Am. 1990 Sep;19(3):617-29.
Gastroesophageal reflux is a recognized clinical problem in infancy. To a great extent it represents a normal behavior that improves with maturation. The identification of appropriate candidates for medical and surgical therapy of GER during infancy is difficult and deserves further study. There are few well-conducted clinical trials of therapy for infantile GER that compare the usual drugs used for adults with GER. Moreover, medications currently licensed for adults are often not approved for pediatric use in the United States. Surgical therapy for GER should be reserved for infants with severe disease that does not respond to medical therapy.
胃食管反流是婴儿期公认的临床问题。在很大程度上，它是一种随着成熟而改善的正常行为。确定婴儿期胃食管反流病（GER）药物和手术治疗的合适候选者很困难，值得进一步研究。很少有关于婴儿GER治疗的精心设计的临床试验将用于成人GER的常用药物进行比较。此外，目前在美国已获批准用于成人的药物通常未获批准用于儿科。GER的手术治疗应仅用于患有严重疾病且药物治疗无效的婴儿。
