Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Therap Adv Gastroenterol. 2012 Jan;5(1):31-6. doi: 10.1177/1756283X11422264.
A proportion of patients with celiac disease have a poor response to a gluten-free diet, which may be due to small-intestinal bacterial overgrowth (SIBO). Treatment with rifaximin is often used in the clinical setting, but there is limited literature to support this practice. In addition, challenges in the diagnosis of SIBO confound response interpretation. Our recent placebo-controlled trial did not demonstrate any improvement in gastrointestinal symptoms after treatment with rifaximin and casts doubt on the utility of lactulose-hydrogen breath testing for SIBO in this population.
一部分乳糜泻患者对无麸质饮食的反应不佳，这可能是由于小肠细菌过度生长（SIBO）引起的。在临床实践中，常采用利福昔明进行治疗，但支持这种治疗方法的文献有限。此外，SIBO 的诊断存在诸多挑战，这也影响了对治疗效果的解读。我们最近的安慰剂对照试验表明，利福昔明治疗并未改善胃肠道症状，这对该人群中乳果糖氢呼气试验诊断 SIBO 的实用性提出了质疑。
