Difference in scopolamine sensitivity during ageing in rats: dichotomy between behavioural repertoire and learning performances.

The effects of different doses of scopolamine in adult and aged rats were compared in two behavioural experiments. The first experiment involved visual reversal learning, while the second experiment investigated individual and social behavioural patterns. Results showed that the same dose of scopolamine was more effective in impairing the reverse discrimination in aged than in adult rats. In contrast, low doses which were effective in modifying behavioural patterns in adults, were inactive in aged rats. This difference in scopolamine sensitivity (supersensitivity versus hyposensitivity), observed between the two types of behaviour, is discussed in relation to age-related functional receptor adaptation, selective changes in muscarinic receptors in the different brain areas and dopaminergic- cholinergic interactions.