Synthélabo Recherche (LERS), 31 Avenue P.V. Couturier, 92220-Bagneux, France.
J Psychopharmacol. 1989 Jan;3(4):198-204. doi: 10.1177/026988118900300402.
Rats were trained to discriminate a dose of the NMDA antagonist MK-801 from saline using a standard, two-lever, operant procedure. The acquisition of this discrimination was rapid, rats reaching criterion performance in a mean of 32 sessions. The discriminative stimulus produced by MK-801 generalized to phencyclidine and (+)N-allylnormetazocine but only low levels of generalization were seen with (-)N-allylnormetazocine and with the anti- ischaemic drug ifenprodil and its derivative SL 82.0715. The MK-801 stimulus was partially antagonized by haloperidol. The results show that MK-801 can produce a discriminative stimulus which is shared by other non-competitive NMDA antagonists which have similar behavioural effects in other procedures. However, ifenprodil and SL 82.0715, which have also been shown to antagonize the effects of NMDA, do not produce similar behavioural effects or discriminative stimuli presumably because they act through a different site.
老鼠被训练使用标准的双杠操作性条件反射程序来区分 NMDA 拮抗剂 MK-801 与生理盐水的剂量。这种辨别能力的获得非常迅速，老鼠在平均 32 次试验中达到了标准表现。MK-801 产生的辨别刺激与苯环己哌啶和 (+)N-allylnormetazocine 相吻合，但与 (-)N-allylnormetazocine 以及抗缺血药物ifenprodil 和其衍生物 SL 82.0715 只有低水平的概括。MK-801 刺激被氟哌啶醇部分拮抗。结果表明，MK-801 可以产生一种辨别刺激，这种刺激与其他具有类似行为效应的非竞争性 NMDA 拮抗剂共享，而ifenprodil 和 SL 82.0715 也被证明可以拮抗 NMDA 的作用，但它们不会产生类似的行为效应或辨别刺激，可能是因为它们作用于不同的部位。
