5-HT1A 受体与重度抑郁症。
5-HT1A Receptors in major depression.
机构信息
MRC Neurochemical Pathology Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK.
出版信息
J Psychopharmacol. 1990 Jan;4(2):69-74. doi: 10.1177/026988119000400204.
PMID:22282930
Abstract
The 5-HT(1A) receptor has been studied using quantitative tritium film auto radiography in post-mortem frontal cortex of 15 cases suffering from major depression and controls matched for age, sex, post-mortem delay and storage time. 5-HT(1A) receptor binding in the depressive cohort was not significantly different from control values. No consistent effects of antidepressant medication or mental state at death were seen on the results.
摘要
使用定量氚化胶片自动放射自显影技术，研究了 15 例患有重度抑郁症和年龄、性别、死后延迟和储存时间匹配的对照组患者死后额叶皮质中的 5-HT（1A）受体。抑郁组的 5-HT（1A）受体结合与对照组无显著差异。在研究结果中，未观察到抗抑郁药物或死亡时精神状态的一致影响。
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