Benetello P, Furlanut M, Zara G, Baraldo M
Institute of Neurology and Clinical Pharmacology, University of Padua, Italy.
Int J Clin Pharmacol Res. 1990;10(3):191-5.
Pharmacokinetics of single dose (25 mg i.m.) of imipramine was studied in geriatric and young adult patients with mood disorders requiring antidepressant treatment. Imipramine and its principal metabolites were determined by means of a high performance liquid chromatography method with electrochemical detection. Serum concentrations analysis was performed according to a bicompartmental open model. A relationship between age and kinetic parameters such as area under the curve, elimination phase constant, half-life and total body clearance was observed. Significant differences were demonstrated between elderly and young adult patients when comparing these parameters. It is concluded that geriatric patients treated with imipramine should receive doses of about 60% of those of young adults.
对需要抗抑郁治疗的老年和年轻成年情绪障碍患者，研究了单剂量（25毫克，肌肉注射）丙咪嗪的药代动力学。采用高效液相色谱法和电化学检测法测定丙咪嗪及其主要代谢产物。血清浓度分析按照双室开放模型进行。观察到年龄与曲线下面积、消除相常数、半衰期和全身清除率等动力学参数之间的关系。比较这些参数时，老年患者和年轻成年患者之间存在显著差异。得出的结论是，用丙咪嗪治疗的老年患者应接受约为年轻成年人剂量60%的药物。
