University of Toronto, ON, Canada.
Expert Rev Respir Med. 2012 Feb;6(1):27-35. doi: 10.1586/ers.11.93.
The number of patients listed for lung transplantation largely exceeds the number of available transplantable organs because of both a shortage of organ donors and a low utilization rate of donor lungs. Normothermic ex vivo lung perfusion (EVLP) is a method that maintains the organ in physiologically protective conditions outside the body during preservation, and shows great promise to increase utilization of donor lungs by allowing more accurate evaluation, as well as treatment and repair, of damaged donor lungs prior to transplantation. This article will cover the rationale, technical details and results of experimental and clinical studies with EVLP. The significant potential applications of EVLP in lung transplantation, lung regeneration and oncology are discussed.
由于器官捐献者短缺和供体肺利用率低，接受肺移植的患者人数大大超过了可用于移植的器官数量。常温离体肺灌注（EVLP）是一种在保存过程中使器官在生理保护条件下保持在体外的方法，它通过允许在移植前更准确地评估、治疗和修复受损的供体肺，显示出增加供体肺利用率的巨大潜力。本文将介绍 EVLP 的实验和临床研究的基本原理、技术细节和结果。讨论了 EVLP 在肺移植、肺再生和肿瘤学中的重要潜在应用。
