Department of Internal Medicine, National Taiwan University Hospital, Taipei.
Int J Tuberc Lung Dis. 2011 Oct;15(10):1415-20. doi: 10.5588/ijtld.10.0786.
Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD).
To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD.
From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma.
Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age >65 years and higher serum sTREM-1 level were associated with worse 6-month survival.
In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.
血清生物标志物在非结核分枝杆菌肺病（NTM-LD）患者中很少被研究。
研究可溶性髓系细胞触发受体-1（sTREM-1）和其他炎症标志物在 NTM-LD 中的作用。
2009 年 4 月至 2010 年 3 月，对临床和影像学疑似 NTM-LD 的 NTM 培养阳性呼吸道标本患者评估 sTREM-1、C 反应蛋白、降钙素原和干扰素-γ的血清水平。
86 例患者中，60 例符合 NTM-LD 诊断。使用受试者工作特征曲线分析，血清 sTREM-1 对 NTM-LD 和定植具有最高的鉴别能力（曲线下面积=0.714）。使用 180 pg/ml 的截断值，sTREM-1 的敏感性和特异性分别为 58%和 89%。Logistic 回归分析显示，鸟分枝杆菌复合群、堪萨斯分枝杆菌、痰抗酸染色阳性和较高的血清 sTREM-1 水平是 NTM-LD 的独立危险因素。年龄>65 岁和较高的血清 sTREM-1 水平与 6 个月生存率较差相关。
对于临床疑似 NTM-LD 的 NTM 培养阳性呼吸道标本患者，血清 sTREM-1 水平测量可能有助于诊断和预测 NTM-LD 的预后。
