中枢神经轴区域麻醉与全身麻醉对术后自然杀伤 T 淋巴细胞功能影响的荟萃分析。
Meta-analysis of the effect of central neuraxial regional anesthesia compared with general anesthesia on postoperative natural killer T lymphocyte function.
机构信息
Department of Anaesthesia, Mater Misericordiae University Hospital, Eccles St., Dublin 7, Ireland.
出版信息
J Clin Anesth. 2012 Feb;24(1):3-7. doi: 10.1016/j.jclinane.2011.09.001.
STUDY OBJECTIVE
To compare the effect of central neuraxial (spinal or epidural) anesthesia with general anesthesia on postoperative natural killer (NK) T lymphocyte function.
DESIGN
Meta-analysis.
SETTING
University-affiliated hospital.
MEASUREMENTS
A systematic search of the medical literature from 1966 to 2009 yielded 5 eligible studies with a total of 184 patients who received neuraxial blockade. Natural killer T lymphocyte function was studied.
MAIN RESULTS
There was significant heterogeneity between the studies [I(2) = 94.4% (95% CI= 90.3-96.2%)]. Overall fixed-effect odds ratio was 0.86 (0.66-1.14, P = 0.25). The random-effect odds ratio was 1.13 (0.26-4.92, P = 0.79).
CONCLUSION
Anesthetic technique does not appear to significantly affect postoperative NK T lymphocyte function. Given the heterogeneity observed, further clinical studies in cancer patients of the effect of anesthetic technique on immune function in general, and NK T lymphocyte function in particular, are needed.
研究目的
比较全身麻醉与中枢神经（椎管内麻醉或硬膜外麻醉）麻醉对术后自然杀伤（NK）T 淋巴细胞功能的影响。
设计
荟萃分析。
地点
大学附属医院。
测量方法
系统检索 1966 年至 2009 年的医学文献，共纳入 5 项符合条件的研究，总计 184 例接受中枢神经阻滞的患者。研究了 NK T 淋巴细胞功能。
主要结果
研究之间存在显著的异质性[I(2) = 94.4%（95%可信区间= 90.3-96.2%）]。总体固定效应比值比为 0.86（0.66-1.14，P = 0.25）。随机效应比值比为 1.13（0.26-4.92，P = 0.79）。
结论
麻醉技术似乎并不显著影响术后 NK T 淋巴细胞功能。鉴于观察到的异质性，需要进一步研究癌症患者中麻醉技术对免疫功能的影响，特别是对 NK T 淋巴细胞功能的影响。
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