Department of Anesthesiology, Xi'an Children's Hospital, Xi'an, Shaanxi 710032, China.
Department of Anesthesiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USA.
Can J Gastroenterol Hepatol. 2018 Apr 1;2018:7940603. doi: 10.1155/2018/7940603. eCollection 2018.
Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body's immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance.
结直肠癌（CRC）是全球导致高发病率和死亡率的主要原因。手术切除是 CRC 的最有效治疗方法。然而，手术反应引起的应激会破坏机体的免疫力，增加癌症扩散和转移的可能性。麻醉是控制应激反应的有效方法，最近的基础和临床研究表明，麻醉和相关药物在围手术期可以直接或间接影响结直肠癌患者的免疫系统。因此，这些药物可能会影响 CRC 手术患者的预后。本综述旨在总结目前关于麻醉剂和相关药物对 CRC 患者围手术期免疫功能及术后复发转移影响的相关数据。确定最适合 CRC 患者的麻醉方法至关重要。
