麻醉对结直肠癌患者免疫系统的影响。
The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients.
机构信息
Department of Anesthesiology, Xi'an Children's Hospital, Xi'an, Shaanxi 710032, China.
Department of Anesthesiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52246, USA.
出版信息
Can J Gastroenterol Hepatol. 2018 Apr 1;2018:7940603. doi: 10.1155/2018/7940603. eCollection 2018.
Abstract
Colorectal cancer (CRC) is the key leading cause of high morbidity and mortality worldwide. Surgical excision is the most effective treatment for CRC. However, stress caused by surgery response can destroy the body's immunity and increase the likelihood of cancer dissemination and metastasis. Anesthesia is an effective way to control the stress response, and recent basic and clinical research has shown that anesthesia and related drugs can directly or indirectly affect the immune system of colorectal cancer patients during the perioperative period. Thus, these drugs may affect the prognosis of CRC surgery patients. This review is intended to summarize currently available data regarding the effects of anesthetics and related drugs on perioperative immune function and postoperative recurrence and metastasis in CRC patients. Determining the most suitable anesthesia for patients with CRC is of utmost importance.
摘要
结直肠癌（CRC）是全球导致高发病率和死亡率的主要原因。手术切除是 CRC 的最有效治疗方法。然而，手术反应引起的应激会破坏机体的免疫力，增加癌症扩散和转移的可能性。麻醉是控制应激反应的有效方法，最近的基础和临床研究表明，麻醉和相关药物在围手术期可以直接或间接影响结直肠癌患者的免疫系统。因此，这些药物可能会影响 CRC 手术患者的预后。本综述旨在总结目前关于麻醉剂和相关药物对 CRC 患者围手术期免疫功能及术后复发转移影响的相关数据。确定最适合 CRC 患者的麻醉方法至关重要。
相似文献
1
The Effect of Anesthesia on the Immune System in Colorectal Cancer Patients.麻醉对结直肠癌患者免疫系统的影响。
Can J Gastroenterol Hepatol. 2018 Apr 1;2018:7940603. doi: 10.1155/2018/7940603. eCollection 2018.
2
Anesthesia and colorectal cancer - The perioperative period as a window of opportunity?麻醉与结直肠癌——围手术期是一个机会窗口吗？
Eur J Surg Oncol. 2016 Sep;42(9):1286-95. doi: 10.1016/j.ejso.2016.05.004. Epub 2016 May 24.
3
Impact of anesthesia for cancer surgery: Continuing professional development.癌症手术麻醉的影响：持续专业发展。
Can J Anaesth. 2013 Dec;60(12):1248-69. doi: 10.1007/s12630-013-0037-1.
4
The proposed mechanism of action during different pain management techniques on expression of cytolytic molecule perforin in patients after colorectal cancer surgery.不同疼痛管理技术对结直肠癌手术后患者细胞溶解分子穿孔素表达的作用机制。
Med Hypotheses. 2011 Mar;76(3):450-2. doi: 10.1016/j.mehy.2010.11.019. Epub 2010 Dec 30.
5
Immune Checkpoint Modulation in Colorectal Cancer: What's New and What to Expect.结直肠癌的免疫检查点调节：最新进展与展望。
J Immunol Res. 2015;2015:158038. doi: 10.1155/2015/158038. Epub 2015 Oct 29.
6
Anesthetics, immune cells, and immune responses.麻醉剂、免疫细胞与免疫反应。
J Anesth. 2008;22(3):263-77. doi: 10.1007/s00540-008-0626-2. Epub 2008 Aug 7.
7
Impact of anesthesia on cancer recurrence.麻醉对癌症复发的影响。
Rev Esp Anestesiol Reanim. 2015 Dec;62(10):570-5. doi: 10.1016/j.redar.2015.04.003. Epub 2015 May 27.
8
[Improved immunologic response after laparoscopic versus open colorectal cancer surgery].[腹腔镜与开腹结直肠癌手术后免疫反应的改善]
Ugeskr Laeger. 2015 Jul 13;177(29).
9
[Effects of anesthesia on the immune system].[麻醉对免疫系统的影响]
Rev Esp Anestesiol Reanim. 1988 May-Jun;35(3):152-6.
10
Anesthesia drugs, immunity, and long-term outcome.麻醉药物、免疫与长期预后。
Curr Opin Anaesthesiol. 2006 Aug;19(4):423-8. doi: 10.1097/01.aco.0000236143.61593.14.
引用本文的文献
1
Impact of propofol on gastrointestinal cancer outcomes: A review of cellular behavior, growth, and metastasis.丙泊酚对胃肠道癌结局的影响：细胞行为、生长和转移的综述
World J Clin Oncol. 2025 Jul 24;16(7):104727. doi: 10.5306/wjco.v16.i7.104727.
2
A commentary on "Predicting disease-free survival following curative-intent resection of right-sided colon cancer using a pre-and post-operative nomogram: a prospective observational cohort study".对“使用术前和术后列线图预测右侧结肠癌根治性切除术后无病生存率：一项前瞻性观察队列研究”的述评
Int J Surg. 2025 Sep 1;111(9):6585-6587. doi: 10.1097/JS9.0000000000002760. Epub 2025 Jun 17.
3
Comparison of inhalation and total intravenous anesthesia on inflammatory markers in microdiscectomy: a double-blind study.吸入麻醉与全静脉麻醉对显微椎间盘切除术炎症标志物影响的比较：一项双盲研究
BMC Anesthesiol. 2025 May 10;25(1):238. doi: 10.1186/s12871-025-03119-6.
4
A retrospective observational study of risk factors for postoperative meningitis following resection of meningioma.一项关于脑膜瘤切除术后发生脑膜炎危险因素的回顾性观察研究。
J Int Med Res. 2025 Mar;53(3):3000605251327527. doi: 10.1177/03000605251327527. Epub 2025 Mar 27.
5
Effects of propofol-based total intravenous anesthesia versus desflurane anesthesia on natural killer cell cytotoxicity after hepatocellular carcinoma resection.丙泊酚全凭静脉麻醉与地氟烷麻醉对肝细胞癌切除术后自然杀伤细胞细胞毒性的影响。
J Anaesthesiol Clin Pharmacol. 2024 Jul-Sep;40(3):395-402. doi: 10.4103/joacp.joacp_174_23. Epub 2023 Aug 16.
6
The role of perioperative factors in the prognosis of cancer patients: A coin has two sides.围手术期因素在癌症患者预后中的作用：事物都有两面性。
J Biomed Res. 2024 Sep 25;39(2):1-12. doi: 10.7555/JBR.38.20240164.
7
Pain in Colorectal Surgery: How Does It Occur and What Tools Do We Have for Treatment?结直肠手术中的疼痛：它是如何发生的，我们有哪些治疗手段？
J Clin Med. 2023 Oct 26;12(21):6771. doi: 10.3390/jcm12216771.
8
Immunomodulatory and pro-oncologic effects of ketamine and isoflurane anesthetics in a murine model.氯胺酮和异氟烷麻醉剂在小鼠模型中的免疫调节和促瘤作用。
PLoS One. 2023 Oct 10;18(10):e0292492. doi: 10.1371/journal.pone.0292492. eCollection 2023.
9
The Immunomodulatory Effect of Various Anaesthetic Practices in Patients Undergoing Gastric or Colon Cancer Surgery: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.各种麻醉方式对胃癌或结肠癌手术患者的免疫调节作用：一项随机临床试验的系统评价和荟萃分析
J Clin Med. 2023 Sep 18;12(18):6027. doi: 10.3390/jcm12186027.
10
Postoperative Changes in Systemic Immune Tolerance Following Major Oncologic versus Minor Maxillofacial Surgery.大型肿瘤手术与小型颌面外科手术后全身免疫耐受的术后变化
Cancers (Basel). 2023 Jul 25;15(15):3755. doi: 10.3390/cancers15153755.
本文引用的文献
1
Cancer Statistics, 2017.《2017 年癌症统计》
CA Cancer J Clin. 2017 Jan;67(1):7-30. doi: 10.3322/caac.21387. Epub 2017 Jan 5.
2
Contributions of the adaptive immune system to mood regulation: Mechanisms and pathways of neuroimmune interactions.适应性免疫系统对情绪调节的贡献：神经免疫相互作用的机制和途径。
Prog Neuropsychopharmacol Biol Psychiatry. 2017 Oct 3;79(Pt A):49-57. doi: 10.1016/j.pnpbp.2016.09.003. Epub 2016 Sep 6.
3
Effect of continuous infusion of midazolam on immune function in pediatric patients after surgery.咪达唑仑持续输注对小儿患者术后免疫功能的影响。
Genet Mol Res. 2015 Aug 21;14(3):10007-14. doi: 10.4238/2015.August.21.7.
4
Non-steroidal anti-inflammatory drugs use is associated with reduced risk of inflammation-associated cancers: NIH-AARP study.美国国立卫生研究院-美国退休人员协会研究：使用非甾体抗炎药与炎症相关癌症风险降低有关。
PLoS One. 2014 Dec 31;9(12):e114633. doi: 10.1371/journal.pone.0114633. eCollection 2014.
5
Yin and yang of tumor inflammation: how innate immune suppressors shape the tumor microenvironments.肿瘤炎症的阴阳两面：固有免疫抑制剂如何塑造肿瘤微环境。
Int J Cancer. 2014 Sep 15;135(6):1277-85. doi: 10.1002/ijc.28626. Epub 2013 Nov 30.
6
Does regional anaesthesia and analgesia or opioid analgesia influence recurrence after primary cancer surgery? An update of available evidence.区域麻醉和镇痛或阿片类镇痛药是否会影响原发性癌症手术后的复发？现有证据的更新。
Best Pract Res Clin Anaesthesiol. 2013 Dec;27(4):441-56. doi: 10.1016/j.bpa.2013.10.005. Epub 2013 Oct 15.
7
Phenotypic skewing of macrophages in vitro by secreted factors from colorectal cancer cells.结肠癌细胞分泌因子对体外巨噬细胞表型的影响
PLoS One. 2013 Sep 18;8(9):e74982. doi: 10.1371/journal.pone.0074982. eCollection 2013.
8
Perioperative ketorolac in high risk breast cancer patients. Rationale, feasibility and methodology of a prospective randomized placebo-controlled trial.围手术期酮咯酸在高危乳腺癌患者中的应用。一项前瞻性随机安慰剂对照试验的原理、可行性和方法学。
Med Hypotheses. 2013 Oct;81(4):707-12. doi: 10.1016/j.mehy.2013.07.033. Epub 2013 Aug 9.
9
[Large granular lymphocyte leukemia: clinical and pathogenic aspects].[大颗粒淋巴细胞白血病：临床与发病机制方面]
Rev Med Interne. 2013 Sep;34(9):553-60. doi: 10.1016/j.revmed.2012.12.020. Epub 2013 Aug 5.
10
Tumor-associated macrophages as a paradigm of macrophage plasticity, diversity, and polarization: lessons and open questions.肿瘤相关巨噬细胞作为巨噬细胞可塑性、多样性和极化的典范：经验和未解决的问题。
Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1478-83. doi: 10.1161/ATVBAHA.113.300168.
Zotero 插件