Trauma Hospital Graz, Austria.
Injury. 2012 Jul;43(7):1041-51. doi: 10.1016/j.injury.2011.12.016. Epub 2012 Jan 28.
Locking compression plates are used in various configurations with lack of detailed information on consequent bone healing.
In this in vivo study in sheep 5 different applications of locking compression plate (LCP) were tested using a 45° oblique osteotomy simulating simple fracture pattern. 60 Swiss Alpine sheep where assigned to 5 different groups with 12 sheep each (Group 1: interfragmentary lag screw and an LCP fixed with standard cortex screws as neutralisation plate; Group 2: interfragmentary lag screw and LCP with locking head screws; Group 3: compression plate technique (hybrid construct); Group 4: internal fixator without fracture gap; Group 5: internal fixator with 3mm gap at the osteotomy site). One half of each group (6 sheep) was monitored for 6 weeks, and the other half (6 sheep) where followed for 12 weeks.
X-rays at 3, 6, 9 and 12 weeks were performed to monitor the healing process. After sacrifice operated tibiae were tested biomechanically for nondestructive torsion and compared to the tibia of the healthy opposite side. After testing specimens were processed for microradiography, histology, histomorphometry and assessment of calcium deposition by fluorescence microscopy.
In all groups bone healing occurred without complications. Stiffness in biomechanical testing showed a tendency for higher values in G2 but results were not statistically significant. Values for G5 were significantly lower after 6 weeks, but after 12 weeks values had improved to comparable results. For all groups, except G3, stiffness values improved between 6 and 12 weeks. Histomorphometrical data demonstrate endosteal callus to be more marked in G2 at 6 weeks.
All five configurations resulted in undisturbed bone healing and are considered safe for clinical application.
锁定加压钢板以各种构型应用，但对于随之而来的骨愈合情况缺乏详细信息。
在这项绵羊体内研究中，使用模拟简单骨折模式的 45°斜行截骨术对 5 种不同的锁定加压钢板（LCP）应用进行了测试。将 60 只瑞士高山绵羊分为 5 个不同的组，每组 12 只（组 1：骨折间拉力螺钉和标准皮质螺钉固定的 LCP 作为中和板；组 2：骨折间拉力螺钉和带锁定头螺钉的 LCP；组 3：加压钢板技术（混合结构）；组 4：无骨折间隙的内固定器；组 5：截骨部位有 3mm 间隙的内固定器）。每组的一半（6 只）监测 6 周，另一半（6 只）监测 12 周。
在 3、6、9 和 12 周时进行 X 射线检查以监测愈合过程。在牺牲后，对手术胫骨进行非破坏性扭转生物力学测试，并与健康对侧胫骨进行比较。测试后，标本进行微射线照相、组织学、组织形态计量学和荧光显微镜评估钙沉积。
所有组均无并发症愈合。生物力学测试中的刚度显示 G2 中的值有升高的趋势，但结果无统计学意义。G5 在 6 周时的值明显较低，但在 12 周时，值已提高到可比结果。除 G3 外，所有组的刚度值在 6 至 12 周之间均有所提高。组织形态计量学数据显示，G2 在 6 周时内骨痂更为明显。
所有 5 种构型均导致未受干扰的骨愈合，并且被认为可安全用于临床应用。
