Department of Cardiology, Center for Inflammation and Cancer, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mol Cell. 2012 Jan 27;45(2):210-21. doi: 10.1016/j.molcel.2011.12.026.
Small ubiquitin-like modifier (SUMO) modification has emerged as an important regulatory mechanism during embryonic development. However, it is not known whether SUMOylation plays a role in the development of the immune system. Here, we show that SUMO-specific protease 1 (SENP1) is essential for the development of early T and B cells. STAT5, a key regulator of lymphoid development, is modified by SUMO-2 and is specifically regulated by SENP1. In the absence of SENP1, SUMO-2 modified STAT5 accumulates in early lymphoid precursors, resulting in a block in its acetylation and subsequent signaling. These results demonstrate a crucial role of SENP1 in the regulation of STAT5 activation during early lymphoid development.
小泛素样修饰物 (SUMO) 修饰已成为胚胎发育过程中的一个重要调控机制。然而，目前尚不清楚 SUMO 化是否在免疫系统发育中发挥作用。在这里，我们表明 SUMO 特异性蛋白酶 1 (SENP1) 对于早期 T 和 B 细胞的发育是必需的。STAT5 是淋巴样发育的关键调节因子，它被 SUMO-2 修饰，并被 SENP1 特异性调节。在 SENP1 缺失的情况下，SUMO-2 修饰的 STAT5 在早期淋巴样前体中积累，导致其乙酰化和随后的信号转导受阻。这些结果表明 SENP1 在早期淋巴样发育过程中调节 STAT5 激活中起着关键作用。
